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syndecan 1

Summary

Gene Symbol

Sdc1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25216

PubChem

25216

Alliance of Genome Resources

RGD:3648

Annotation

Keyword

Heparan sulfate
Phosphoprotein
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HAM5
P26260

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IEP	12135485
Sertoli cell development	IEP	12453641
response to calcium ion	IEP	12135485
positive regulation of extracellular exosome assembly	ISO
striated muscle cell development	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

myoblast development

muscle cell development [inference]

striated muscle cell development

cell motility [inference]

cell migration

reproductive process [inference]

developmental process involved in reproduction [inference]

Sertoli cell development

developmental process [inference]

developmental process involved in reproduction [inference]

Sertoli cell development

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

myoblast development

muscle cell development [inference]

striated muscle cell development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

myoblast development

muscle cell development [inference]

striated muscle cell development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to toxic substance

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to hydrogen peroxide

response to organophosphorus [inference]

response to cAMP

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to hydrogen peroxide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to salt [inference]

response to calcium ion

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of exosomal secretion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of exosomal secretion

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of extracellular exosome assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of exosomal secretion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of extracellular exosome assembly [inference]

positive regulation of extracellular exosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of extracellular exosome assembly

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	ISO
protein-containing complex	IDA	11431373
plasma membrane	ISO
extracellular region	IEA
cell surface	IBA ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11431373 26601939 9089390
extracellular matrix binding	TAS	12135485
identical protein binding	ISO
cargo receptor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

extracellular matrix binding

cargo receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Syndecan

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell migration

Displaying **all 4** entries
InterPro
Neurexin/syndecan/glycophorin C
Syndecan, conserved site
Syndecan/Neurexin domain
Syndecan

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
protein-containing complex	PMID:11431373

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:1168	familial hyperlipidemia	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:576	proteinuria	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:8567	Hodgkin's lymphoma	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 75 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Nannospalax galili	103726599	1026970_0:004d07	NANGA12816
Fukomys damarensis	104857965	885580_0:00026f
Macaca nemestrina	105479875		MACNE22269
Mandrillus leucophaeus	105533090		MANLE05856
Cercocebus atys	105578575		CERAT08306
Aotus nancymaae	105717932		AOTNA24327
Propithecus coquereli	105817414		PROCO07869
Microcebus murinus	105884037		MICMU11254
Dipodomys ordii	105983605	10020_0:0013d0
Equus asinus asinus	106835580		EQUAS08738