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lysocardiolipin acyltransferase 1

Summary

Gene Symbol

LCLAT1

Aliases

1ysophospholipid acyltransferase 6
AGPAT8
ALCAT1
FLJ37965
LPLAT6
acyl-CoA:lysocardiolipin acyltransferase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

253558

HGNC

26756

KEGG Gene ID

hsa:253558

PubChem

253558

Alliance of Genome Resources

HGNC:26756

Annotation

Keyword

Acetylation
Acyltransferase
Alternative splicing
Developmental protein
Endoplasmic reticulum
Phospholipid biosynthesis
Phospholipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6UWP7	1-acylglycerol-3-phosphate O-acyltransferase 8 Acyl-CoA:lysocardiolipin acyltransferase 1
B4DYR5
B4DM26

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphatidic acid biosynthetic process	TAS
phosphatidylinositol acyl-chain remodeling	IBA
CDP-diacylglycerol biosynthetic process	IEA
cardiolipin acyl-chain remodeling	TAS	19075029

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
endoplasmic reticulum membrane	TAS
endoplasmic reticulum	IBA IDA	16620771 19075029
endomembrane system	IBA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
acyltransferase activity	IBA
1-acylglycerol-3-phosphate O-acyltransferase activity	IDA TAS	16620771 19075029
protein binding	IPI	25416956 32296183
O-acyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity [inference]

lysophosphatidic acid acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Acyltransferase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
phosphatidylinositol acyl-chain remodeling
transferase activity

Displaying **all 2** entries
InterPro
Acyltransferase, C-terminal domain
Phospholipid/glycerol acyltransferase

KEGG BRITE Database

Orthology

K13513

Name

lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]

References

Rhea

RHEA:19709

a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA

CoA + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.3.1.51

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006280
Gene Name: lysocardiolipin acyltransferase 1

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179031		WB:WBGene00020264
Caenorhabditis elegans	179032		WB:WBGene00022646
Caenorhabditis elegans	186277		WB:WBGene00044631
Mus musculus	225010		MGI:2684937	MOUSE21158
Rattus norvegicus	362702		RGD:1565906	RATNO35178
Danio rerio	406554		ZFIN:ZDB-GENE-081211-2	DANRE06422
Pan troglodytes	459129	9598_0:000952		PANTR27347
Canis lupus familiaris	483023			CANLF05016
Bos taurus	520912			BOVIN02729
Macaca mulatta	704859			MACMU08204

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements