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lysocardiolipin acyltransferase 1

Summary

Gene Symbol

LCLAT1

Aliases

1ysophospholipid acyltransferase 6
AGPAT8
ALCAT1
FLJ37965
LPLAT6
acyl-CoA:lysocardiolipin acyltransferase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

253558

HGNC

26756

KEGG Gene ID

hsa:253558

PubChem

253558

Alliance of Genome Resources

HGNC:26756

Annotation

Keyword

Acetylation
Acyltransferase
Alternative splicing
Developmental protein
Endoplasmic reticulum
Phospholipid biosynthesis
Phospholipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6UWP7	1-acylglycerol-3-phosphate O-acyltransferase 8 Acyl-CoA:lysocardiolipin acyltransferase 1
B4DYR5
B4DM26

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
CDP-diacylglycerol biosynthetic process	IEA
cardiolipin acyl-chain remodeling		19075029
phosphatidylinositol acyl-chain remodeling	IBA
phosphatidic acid biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA	16620771 19075029
cytosol	IDA
endoplasmic reticulum membrane
endomembrane system	IBA
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity	IDA TAS	16620771 19075029
O-acyltransferase activity
acyltransferase activity	IBA
protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity [inference]

lysophosphatidic acid acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K13513

Name

lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]

References

Rhea

RHEA:19709

a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA

CoA + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.3.1.51

PMID

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050156	idiopathic pulmonary fibrosis	DisGeNET
DOID:12123	postinflammatory pulmonary fibrosis	DisGeNET
DOID:2723	dermatitis	DisGeNET
DOID:2797	idiopathic interstitial pneumonia	DisGeNET DisGeNET
DOID:3770	pulmonary fibrosis	DisGeNET
DOID:552	pneumonia	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006280
Gene Name: lysocardiolipin acyltransferase 1

Ortholog

Displaying entries **11 - 20** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Salmo trutta	115172447		SALTR72906
Gadus morhua	115543706		GADMO49814
Oryzias latipes	101155556		ORYLA10266
Oreochromis niloticus	100710226		ORENI31082
Sparus aurata	115566008		SPAAU03816
Xenopus laevis	108716497	Xenbase:XB-GENE-6488314
Xenopus laevis	108717675	Xenbase:XB-GENE-17342005
Xenopus tropicalis	100216057	Xenbase:XB-GENE-5993059
Chrysemys picta bellii	101951946		CHRPI34104
Pseudonaja textilis	113433207		PSETE03742

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements