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contactin 2

Summary

Gene Symbol

Cntn2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25356

PubChem

25356

Alliance of Genome Resources

RGD:3821

Annotation

Keyword

Cell adhesion
Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Immunoglobulin domain
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G3V758
P22063	Axonal glycoprotein TAG-1 Axonin-1 Transient axonal glycoprotein 1
A6IC54

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 58 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	ISO
microtubule cytoskeleton organization	IEA
neuron migration	ISO
G protein-coupled adenosine receptor signaling pathway	ISO
G protein-coupled adenosine receptor signaling pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway [inference]

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

axon ensheathment in central nervous system [inference]

central nervous system myelination

myelination [inference]

central nervous system myelination

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular developmental process [inference]

cell differentiation [inference]

cell motility [inference]

cell migration [inference]

neuron migration

interneuron migration [inference]

cerebral cortex GABAergic interneuron migration

forebrain cell migration [inference]

telencephalon cell migration [inference]

substrate-independent telencephalic tangential migration [inference]

substrate-independent telencephalic tangential interneuron migration [inference]

interneuron migration from the subpallium to the cortex [inference]

cerebral cortex GABAergic interneuron migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to juxtaparanode region of axon

protein localization to axon [inference]

protein localization to juxtaparanode region of axon

establishment of protein localization to juxtaparanode region of axon

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

membrane organization [inference]

neuronal ion channel clustering [inference]

clustering of voltage-gated potassium channels

presynaptic membrane organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

feeding behavior [inference]

eating behavior [inference]

reduction of food intake in response to dietary excess

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to dietary excess

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to juxtaparanode region of axon

protein localization to axon [inference]

protein localization to juxtaparanode region of axon

establishment of protein localization to juxtaparanode region of axon

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

establishment of protein localization [inference]

establishment of protein localization to juxtaparanode region of axon

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to juxtaparanode region of axon

protein localization to axon [inference]

protein localization to juxtaparanode region of axon

establishment of protein localization to juxtaparanode region of axon

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

regulation of adenosine receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

regulation of adenosine receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis

regulation of axonogenesis [inference]

regulation of axon diameter

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

regulation of glial cell differentiation [inference]

regulation of astrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway [inference]

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled purinergic receptor signaling pathway [inference]

G protein-coupled adenosine receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

regulation of adenosine receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

regulation of glial cell differentiation [inference]

regulation of astrocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenosine receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

regulation of axon diameter

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	18179895
plasma membrane	IBA
plasma membrane	IEA
cell surface	ISO
cell surface	TAS	2317872

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

cell body [inference]

neuronal cell body

side of membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
carbohydrate binding	ISO
carbohydrate binding	IEA
cell adhesion mediator activity	ISO
cell adhesion mediator activity	IEA
cell-cell adhesion mediator activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cell adhesion molecule binding [inference]

cell adhesion mediator activity

cell-cell adhesion mediator activity

carbohydrate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Down syndrome cell adhesion molecule-like protein

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
brain development
cell-cell adhesion mediator activity

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	1272	FB:FBgn0037240
Drosophila melanogaster	5067	FB:FBgn0037240
Homo sapiens	6900	Xenbase:XB-GENE-6070188	HUMAN54343
Drosophila melanogaster	12805	FB:FBgn0037240
Drosophila melanogaster	18488	FB:FBgn0037240
Mus musculus	21367	Xenbase:XB-GENE-6070188	MOUSE28925
Xenopus tropicalis	25356	Xenbase:XB-GENE-6070188
Drosophila melanogaster	27255	FB:FBgn0037240
Drosophila melanogaster	27256	FB:FBgn0037240
Danio rerio	40553	ZFIN:ZDB-GENE-990630-12

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements