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brevican

Summary

Gene Symbol

Bcan

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25393

PubChem

25393

Alliance of Genome Resources

RGD:2194

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
GPI-anchor
Hyaluronic acid
Immunoglobulin domain
Lectin
Phosphoprotein
Proteoglycan
Reference proteome
Repeat
Signal
Sushi

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P55068	Brain-enriched hyaluronan-binding protein
A6J642
A6J643
G3V8G4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IDA	11208904
hippocampus development	IEA ISO
neuron projection extension	IDA	11208904
regulation of neuronal synaptic plasticity	IEP	15935069
synapse maturation	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

gliogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

synapse maturation

developmental process [inference]

developmental maturation [inference]

synapse maturation

anatomical structure development [inference]

hippocampus development

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

gliogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular matrix	ISO
side of membrane	IEA
extracellular region	IEA
axon initial segment	IDA	17709431
cell surface	IDA	12799382

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix [inference]

perisynaptic extracellular matrix

perineuronal net

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
hyaluronic acid binding	IEA
carbohydrate binding	IEA

GO Hierarchy

molecular function

binding [inference]

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

hyaluronic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

brevican core protein

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
central nervous system development
hyaluronic acid binding
positive regulation of neuroblast proliferation
skeletal system development

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InterPro
C-type lectin fold
C-type lectin, conserved site
C-type lectin-like/link domain superfamily
C-type lectin-like
EGF-like domain
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
node of Ranvier	PMID:17709431
extracellular space	PMID:7592978
dendrite	PMID:7592978
axon initial segment	PMID:17709431
perineuronal net	PMID:16644727
axon	PMID:17709431
cell surface	PMID:12799382
synaptic membrane	PMID:7592978

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **104** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pan paniscus	100971591		PANPA02753
Papio anubis	101009251		PAPAN18177
Saimiri boliviensis boliviensis	101031830		SAIBB29202
Ovis aries	101105963		SHEEP00966
Gorilla gorilla gorilla	101152445		GORGO18404
Octodon degus	101568649	10160_0:00150d	OCTDE06804
Jaculus jaculus	101614909	51337_0:004b06
Mustela putorius furo	101672716		MUSPF02175
Heterocephalus glaber	101719389	10181_0:0046dc
Mesocricetus auratus	101823135	10036_0:0024c2