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brevican

Summary

Gene Symbol

Bcan

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25393

PubChem

25393

Alliance of Genome Resources

RGD:2194

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
GPI-anchor
Hyaluronic acid
Immunoglobulin domain
Lectin
Phosphoprotein
Proteoglycan
Reference proteome
Repeat
Signal
Sushi

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P55068	Brain-enriched hyaluronan-binding protein
A6J642
A6J643
G3V8G4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IDA	11208904
hippocampus development	IEA ISO
neuron projection extension	IDA	11208904
regulation of neuronal synaptic plasticity	IEP	15935069
synapse maturation	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

gliogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

synapse maturation

developmental process [inference]

developmental maturation [inference]

synapse maturation

anatomical structure development [inference]

hippocampus development

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

gliogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular matrix	ISO
side of membrane	IEA
extracellular region	IEA
axon initial segment	IDA	17709431
cell surface	IDA	12799382

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix [inference]

perisynaptic extracellular matrix

perineuronal net

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
hyaluronic acid binding	IEA
carbohydrate binding	IEA

GO Hierarchy

molecular function

binding [inference]

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

hyaluronic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

brevican core protein

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
central nervous system development
hyaluronic acid binding
positive regulation of neuroblast proliferation
skeletal system development

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InterPro
C-type lectin fold
C-type lectin, conserved site
C-type lectin-like/link domain superfamily
C-type lectin-like
EGF-like domain
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
node of Ranvier	PMID:17709431
extracellular space	PMID:7592978
dendrite	PMID:7592978
axon initial segment	PMID:17709431
perineuronal net	PMID:16644727
axon	PMID:17709431
cell surface	PMID:12799382
synaptic membrane	PMID:7592978

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of **104** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Nannospalax galili	103752103	1026970_0:0006ab
Rhinopithecus roxellana	104656729		RHIRO41162
Fukomys damarensis	104876082	885580_0:003e68
Pteropus vampyrus	105296340		PTEVA09351
Macaca nemestrina	105498063		MACNE23498
Mandrillus leucophaeus	105548656		MANLE30994
Cercocebus atys	105594527		CERAT41887
Aotus nancymaae	105715439		AOTNA24793
Propithecus coquereli	105821982		PROCO12290
Microcebus murinus	105873117		MICMU08281