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Guidelines

MIRAGE

mannosidase, alpha, class 2A, member 1

Summary

Gene Symbol

Man2a1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25478

KEGG Gene ID

PubChem

25478

Alliance of Genome Resources

RGD:3038

Annotation

Keyword

Coiled coil
Direct protein sequencing
Disulfide bond
Glycoprotein
Glycosidase
Golgi apparatus
Metal-binding
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P28494	Golgi alpha-mannosidase II Mannosidase alpha class 2A member 1 Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	ISO
liver development	ISO
carbohydrate metabolic process	IEA
mannose metabolic process	IEA
N-glycan processing	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

respiratory gaseous exchange by respiratory system

developmental process [inference]

anatomical structure morphogenesis [inference]

retina morphogenesis in camera-type eye

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal gross anatomical part developmental process [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

lung alveolus development

animal organ development [inference]

gland development [inference]

liver development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of cellular process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
obsolete extracellular space
Golgi apparatus	ISO
Golgi medial cisterna	ISO
cis-Golgi network	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi medial cisterna

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
alpha-mannosidase activity	IBA
alpha-mannosidase activity	IEA
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	ISO
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IDA
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity

alpha-mannosidase activity

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

hydrolase activity, hydrolyzing N-glycosyl compounds

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

H₂O

α-D-mannopyranose

Enzyme

3.2.1.114

PMID

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	4124	HGNC:6824
Mus musculus	17158	MGI:104669
Caenorhabditis elegans	179632	WB:WBGene00010284
Drosophila melanogaster	41126	FB:FBgn0011740

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026