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alpha-Mannosidase class II a

Summary

Gene Symbol

alpha-Man-IIa

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

41126

PubChem

41126

Alliance of Genome Resources

FB:FBgn0011740

Annotation

Keyword

3D-structure
Disulfide bond
Glycosidase
Golgi apparatus
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q24451	Golgi alpha-mannosidase II Golgi alpha-mannosidase IIa Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
A0A0B4KFG0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
rhodopsin biosynthetic process	IMP	24785692
protein glycosylation
encapsulation of foreign target	IMP	22829770
mannose metabolic process	IEA
N-glycan processing	IBA IMP	24785692

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

encapsulation of foreign target

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

organonitrogen compound biosynthetic process [inference]

rhodopsin biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

rhodopsin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

rhodopsin biosynthetic process

organonitrogen compound biosynthetic process [inference]

rhodopsin biosynthetic process

pigment metabolic process [inference]

pigment metabolic process involved in pigmentation [inference]

pigment metabolic process involved in developmental pigmentation [inference]

eye pigment metabolic process [inference]

eye pigment biosynthetic process [inference]

rhodopsin biosynthetic process

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

pigment biosynthetic process [inference]

eye pigment biosynthetic process [inference]

rhodopsin biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

rhodopsin biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

rhodopsin biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

organonitrogen compound biosynthetic process [inference]

rhodopsin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

rhodopsin biosynthetic process

organonitrogen compound biosynthetic process [inference]

rhodopsin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

rhodopsin biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi stack	NAS	11514618
Golgi membrane	IBA IDA	10504337
endoplasmic reticulum	NAS	11514618

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mannosidase activity	IDA	21804530
metal ion binding
alpha-mannosidase activity	IBA IEA
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IDA	10504337
carbohydrate binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity

alpha-mannosidase activity

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

binding [inference]

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha mannosidase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
Gene Ontology
alpha-mannosidase activity
catalytic activity
hydrolase activity, acting on glycosyl bonds
mannose metabolic process
metal ion binding

Displaying **all 8** entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase 38, N-terminal domain superfamily
Glycoside hydrolase families 57/38, central domain superfamily
Glycoside hydrolase family 38, N-terminal domain
Glycoside hydrolase family 38, central domain superfamily
Glycoside hydrolase family 38, central domain
Glycoside hydrolase/deacetylase, beta/alpha-barrel
Glycosyl hydrolase family 38, C-terminal

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
membrane	FB:FBrf0231198
Golgi membrane	PMID:10504337

Rhea

RHEA:56052

H₂O

α-D-mannopyranose

Enzyme

3.2.1.114

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1338	congenital dyserythropoietic anemia	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	4122		HGNC:6825
Homo sapiens	4124		HGNC:6824
Mus musculus	17158		MGI:104669
Rattus norvegicus	25478		RGD:3038
Mus musculus	140481		MGI:2150656
Caenorhabditis elegans	179632		WB:WBGene00010284
Rattus norvegicus	308757		RGD:1310238
Xenopus tropicalis	448465		Xenbase:XB-GENE-981388
Danio rerio	560219		ZFIN:ZDB-GENE-060526-31
Drosophila pseudoobscura	4800594	7237_0:00145d

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements