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leptin
Summary
- Gene Symbol
-
- Lep
- Organism
- Rattus norvegicus (Norway rat)
Annotation
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| angiogenesis | ||
| ovulation from ovarian follicle | ||
| response to hypoxia | ||
| positive regulation of cytokine production |
GO Hierarchy
- positive regulation of cold-induced thermogenesis
- positive regulation of cold-induced thermogenesis
- regulation of cell cycle
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of response to stimulus [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of system process [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of biological quality [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular space | ||
| extracellular space | ||
| extracellular space | ||
| cytoplasm | ||
| cytosol |
| GO Term | Evidence Code | PMID |
|---|---|---|
| hormone activity | ||
| protein binding | ||
| growth factor activity |
|
|
| peptide hormone receptor binding | ||
| peptide hormone receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- leptin a
- Functional Category
-
- G: Carbohydrate transport and metabolism
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Leptin |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:10603 | glucose intolerance | |
| DOID:10605 | short bowel syndrome | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10763 | hypertension | |
| DOID:11476 | osteoporosis | |
| DOID:14018 | alcoholic liver cirrhosis | |
| DOID:14330 | Parkinson's disease | |
| DOID:1924 | hypogonadism | |
| DOID:2018 | hyperinsulinism |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 113450645 | PSETE24636 | ||
| 113891859 | BOBOX16809 | ||
| 114026442 | VOMUR25282 | ||
| 114605318 | PODMU33915 | ||
| 116832980 | CHEAB29608 | ||
| 117018177 | RHIFE12227 | ||
| 117313539 | TURTR00523 | ||
| 118900861 | BALMU12104 | ||
| 122213550 | PANLE22803 |
