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leiomodin 1

Summary

Gene Symbol

LMOD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

25802

PubChem

25802

Alliance of Genome Resources

HGNC:6647

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Cytoskeleton
Disease variant
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P29536	64 kDa autoantigen 1D 64 kDa autoantigen 1D3 64 kDa autoantigen D1 Leiomodin, muscle form Smooth muscle leiomodin Thyroid-associated ophthalmopathy autoantigen

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
muscle contraction	IBA
actin filament organization	IBA
myofibril assembly	IBA
positive regulation of actin filament polymerization	IDA	26370058
actin nucleation	IDA	26370058

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

supramolecular fiber organization [inference]

actin filament organization

actin nucleation

myofibril assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA
cytoskeleton	IBA
striated muscle thin filament	IBA
actin filament	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

myofilament [inference]

striated muscle thin filament

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

contractile fiber [inference]

myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

contractile fiber [inference]

myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

myofibril

polymeric cytoskeletal fiber [inference]

actin filament

Displaying **all 2** entries
GO Term	Evidence Code	PMID
actin binding	IEA
tropomyosin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tropomodulin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
actin filament organization
muscle contraction
myofibril assembly
pointed-end actin filament capping
tropomyosin binding

Displaying **all 2** entries
InterPro
Leucine-rich repeat domain superfamily
Tropomodulin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060610	megacystis-microcolon-intestinal hypoperistalsis syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	25802	Xenbase:XB-GENE-979212
Drosophila melanogaster	29766	FB:FBgn0082582
Drosophila melanogaster	29767	FB:FBgn0082582
Drosophila melanogaster	50876	FB:FBgn0082582
Mus musculus	93689		MOUSE29691
Rattus norvegicus	304816		RATNO06282
Drosophila melanogaster	442721	FB:FBgn0082582
Pan troglodytes	469637		PANTR23362
Bos taurus	532090		BOVIN08996
Monodelphis domestica	100011381		MONDO13655

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements