GlyCosmos Portal

Submissions

leiomodin 1

Summary

Gene Symbol

LMOD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

25802

PubChem

25802

Alliance of Genome Resources

HGNC:6647

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Cytoskeleton
Disease variant
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P29536	64 kDa autoantigen 1D 64 kDa autoantigen 1D3 64 kDa autoantigen D1 Leiomodin, muscle form Smooth muscle leiomodin Thyroid-associated ophthalmopathy autoantigen

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

« First

‹ Prev

1

2
GO Term	Evidence Code	PMID
pointed-end actin filament capping	IEA

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

supramolecular fiber organization [inference]

actin filament organization

actin nucleation

myofibril assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of actin filament polymerization

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA
cytoskeleton	IBA
striated muscle thin filament	IBA
actin filament	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

myofilament [inference]

striated muscle thin filament

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

contractile fiber [inference]

myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

contractile fiber [inference]

myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

myofibril

polymeric cytoskeletal fiber [inference]

actin filament

Displaying **all 2** entries
GO Term	Evidence Code	PMID
actin binding	IEA
tropomyosin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

leiomodin-1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
actin binding
actin filament organization
muscle contraction
myofibril assembly
pointed-end actin filament capping
tropomyosin binding

Displaying **all 3** entries
InterPro
Leucine-rich repeat domain superfamily
Tropomodulin
WH2 domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060610	megacystis-microcolon-intestinal hypoperistalsis syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 53 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	25802	Xenbase:XB-GENE-979212
Drosophila melanogaster	29766	FB:FBgn0082582
Drosophila melanogaster	29767	FB:FBgn0082582
Drosophila melanogaster	50876	FB:FBgn0082582
Mus musculus	93689		MOUSE29691
Rattus norvegicus	304816		RATNO06282
Drosophila melanogaster	442721	FB:FBgn0082582
Pan troglodytes	469637		PANTR23362
Bos taurus	532090		BOVIN08996
Monodelphis domestica	100011381		MONDO13655

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements