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TCDD inducible poly(ADP-ribose) polymerase

Summary

Gene Symbol

TIPARP

Aliases

ARTD14
DDF1
DKFZP434J214
DKFZp686N0351
PARP-1
PARP-7
PARP7
RM1
pART14

Organism

Homo sapiens (human)

External Links

NCBI Gene

25976

HGNC

23696

PubChem

25976

Alliance of Genome Resources

HGNC:23696

Annotation

Keyword

ADP-ribosylation
Glycosyltransferase
NAD
Nucleotidyltransferase
Nucleus
Reference proteome
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q7Z3E1	ADP-ribosyltransferase diphtheria toxin-like 14 Poly [ADP-ribose] polymerase 7 TCDD-inducible poly [ADP-ribose] polymerase
Q05BQ2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 16 in total

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GO Term	Evidence Code	PMID
post-embryonic development	IEA
platelet-derived growth factor receptor signaling pathway	IEA
androgen metabolic process	IEA
negative regulation of gene expression	IMP	23275542
response to 2,3,7,8-tetrachlorodibenzodioxine	IEA

GO Hierarchy

biological process

metabolic process [inference]

hormone metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

hemopoiesis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skeletal system morphogenesis

face morphogenesis

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

smooth muscle tissue development

cell development [inference]

hemopoiesis

animal organ development [inference]

kidney development

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

roof of mouth development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

hemopoiesis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IBA IDA	23275542 30373764

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	IBA IDA	23275542
cis-regulatory region sequence-specific DNA binding	IDA	23275542
NAD+- protein-cysteine ADP-ribosyltransferase activity	IDA	30373764
NAD+-protein ADP-ribosyltransferase activity	IBA IDA	25043379
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

NAD+- protein-cysteine ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

NAD+- protein-cysteine ADP-ribosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

cis-regulatory region sequence-specific DNA binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

cis-regulatory region sequence-specific DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

cis-regulatory region sequence-specific DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 27 in total

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	DisGeNET
DOID:1138	spinal meningioma	DisGeNET
DOID:12549	hepatitis A	DisGeNET
DOID:12689	acoustic neuroma	DisGeNET
DOID:1574	alcohol use disorder	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:2237	hepatitis	DisGeNET
DOID:2394	ovarian cancer	DisGeNET
DOID:2893	cervix carcinoma	DisGeNET
DOID:3565	meningioma	DisGeNET

Ortholog

Displaying entries **11 - 20** of **102** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Haplochromis burtoni	102297672		HAPBU06281
Astatotilapia calliptera	113035912		ASTCA09491
Sparus aurata	115569699		SPAAU18642
Xenopus laevis	108717040	Xenbase:XB-GENE-17341237
Xenopus laevis	108718115	Xenbase:XB-GENE-6486578
Xenopus tropicalis	100127576	Xenbase:XB-GENE-1000138
Chrysemys picta bellii	101935783		CHRPI04173
Crocodylus porosus	109308370		CROPO15061
Pseudonaja textilis	113439816		PSETE11494
Meleagris gallopavo	100546415		MELGA02895

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Acknowledgements