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TCDD inducible poly(ADP-ribose) polymerase

Summary

Gene Symbol

TIPARP

Aliases

ARTD14
DDF1
DKFZP434J214
DKFZp686N0351
PARP-1
PARP-7
PARP7
RM1
pART14

Organism

Homo sapiens (human)

External Links

NCBI Gene

25976

HGNC

23696

PubChem

25976

Alliance of Genome Resources

HGNC:23696

Annotation

Keyword

ADP-ribosylation
Glycosyltransferase
NAD
Nucleotidyltransferase
Nucleus
Reference proteome
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q7Z3E1	ADP-ribosyltransferase diphtheria toxin-like 14 Poly [ADP-ribose] polymerase 7 TCDD-inducible poly [ADP-ribose] polymerase
Q05BQ2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 16 in total

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GO Term	Evidence Code	PMID
post-embryonic development	IEA
platelet-derived growth factor receptor signaling pathway	IEA
androgen metabolic process	IEA
negative regulation of gene expression	IMP	23275542
response to 2,3,7,8-tetrachlorodibenzodioxine	IEA

GO Hierarchy

biological process

metabolic process [inference]

hormone metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

hemopoiesis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skeletal system morphogenesis

face morphogenesis

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

smooth muscle tissue development

cell development [inference]

hemopoiesis

animal organ development [inference]

kidney development

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

roof of mouth development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

hemopoiesis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IBA IDA	23275542 30373764

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	IBA IDA	23275542
cis-regulatory region sequence-specific DNA binding	IDA	23275542
NAD+- protein-cysteine ADP-ribosyltransferase activity	IDA	30373764
NAD+-protein ADP-ribosyltransferase activity	IBA IDA	25043379
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

NAD+- protein-cysteine ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

NAD+- protein-cysteine ADP-ribosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

cis-regulatory region sequence-specific DNA binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

cis-regulatory region sequence-specific DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

cis-regulatory region sequence-specific DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 27 in total

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	DisGeNET
DOID:1138	spinal meningioma	DisGeNET
DOID:12549	hepatitis A	DisGeNET
DOID:12689	acoustic neuroma	DisGeNET
DOID:1574	alcohol use disorder	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:2237	hepatitis	DisGeNET
DOID:2394	ovarian cancer	DisGeNET
DOID:2893	cervix carcinoma	DisGeNET
DOID:3565	meningioma	DisGeNET

Ortholog

Displaying entries **31 - 40** of **102** in total

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Species	Gene ID	Orthologous MAtrix
Gorilla gorilla gorilla	101136815	GORGO29273
Pan paniscus	100986985	PANPA29134
Pan troglodytes	460801	PANTR32508
Pongo abelii	100432481	PONAB25245
Canis lupus familiaris	485728	CANLF09218
Vulpes vulpes	112925407	VULVU19488
Ursus americanus	123801764	URSAM20594
Ailuropoda melanoleuca	100466922	AILME09534
Mustela putorius furo	101679266	MUSPF12174
Felis catus	101085655	FELCA22542

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