glucokinase

Summary
Gene Symbol
  • GCK
Aliases
  • HK4
  • hexokinase 4
Organism
Homo sapiens (human)
External Links
NCBI Gene
2645
HGNC
4195
KEGG Gene ID
hsa:2645
PubChem
2645
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Allosteric enzyme
  • Alternative splicing
  • Coiled coil
  • Cytoplasm
  • Diabetes mellitus
  • Disease variant
  • Glycolysis
  • Kinase
  • Mitochondrion
  • Nucleus
  • Reference proteome
Proteins
Displaying all 2 entries
UniProt Protein Name
P35557
  • Glucokinase
  • Hexokinase type IV
  • Hexokinase-D
Q53Y25
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000106633

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K12407
Name
glucokinase [EC:2.7.1.2]
References
Disease
Disease Ontology
Displaying entries 101 - 110 of 133 in total
DO ID Disease Name Source
DOID:4194 glucose metabolism disease
DOID:4195 hyperglycemia
DOID:4480 achondroplasia
DOID:4766 embryoma
DOID:4905 pancreatic carcinoma
DOID:5082 liver cirrhosis
DOID:5162 arteriolosclerosis
DOID:557 kidney disease
DOID:5679 retinal disease
DOID:5688 Werner syndrome
The Human Phenotype Ontology
Displaying entries 1 - 10 of 72 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000007 Autosomal recessive inheritance
HP:0000077 Abnormality of the kidney
HP:0000107 Renal cyst
HP:0000112 Nephropathy
HP:0000119 Abnormality of the genitourinary system
HP:0000124 Renal tubular dysfunction
HP:0000365 Hearing impairment
HP:0000488 Retinopathy
HP:0000819 Diabetes mellitus
Displaying all 7 entries
Disease ID Disease Name
OMIM:602485
  • hyperinsulinism due to glucokinase deficiency
ORPHA:552
  • maturity-onset diabetes of the young
OMIM:606176
  • permanent neonatal diabetes mellitus 1
ORPHA:79299
  • hyperinsulinism due to glucokinase deficiency
ORPHA:99885
  • permanent neonatal diabetes mellitus
OMIM:125851
  • maturity-onset diabetes of the young type 2
OMIM:125853
  • type 2 diabetes mellitus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024