glucokinase

Summary
Gene Symbol
  • GCK
Aliases
  • HK4
  • hexokinase 4
Organism
Homo sapiens (human)
External Links
NCBI Gene
2645
HGNC
4195
KEGG Gene ID
hsa:2645
PubChem
2645
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Allosteric enzyme
  • Alternative splicing
  • Coiled coil
  • Cytoplasm
  • Diabetes mellitus
  • Disease variant
  • Glycolysis
  • Kinase
  • Mitochondrion
  • Nucleus
  • Reference proteome
Proteins
Displaying all 2 entries
UniProt Protein Name
P35557
  • Glucokinase
  • Hexokinase type IV
  • Hexokinase-D
Q53Y25
Gene Ontology (GO)
GO Hierarchy
Displaying entries 6 - 7 of 7 in total
GO Term Evidence Code PMID
protein binding
fructokinase activity
GO Hierarchy
Human Protein Atlas
ENSG00000106633

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K12407
Name
glucokinase [EC:2.7.1.2]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 133 in total
DO ID Disease Name Source
DOID:0014667 disease of metabolism
DOID:0050424 familial adenomatous polyposis
DOID:0050524 maturity-onset diabetes of the young
DOID:0050759 myotonic dystrophy type 2
DOID:0050782 Zollinger-Ellison syndrome
DOID:0060135 apraxia
DOID:0060260 ptosis
DOID:0060261 congenital ptosis
DOID:0060334 transient neonatal diabetes mellitus
DOID:0060639 permanent neonatal diabetes mellitus
The Human Phenotype Ontology
Displaying entries 21 - 30 of 72 in total
HPO ID HPO Term
HP:0001263 Global developmental delay
HP:0001270 Motor delay
HP:0001324 Muscle weakness
HP:0001325 Hypoglycemic coma
HP:0001488 Bilateral ptosis
HP:0001508 Failure to thrive
HP:0001511 Intrauterine growth retardation
HP:0001513 Obesity
HP:0001518 Small for gestational age
HP:0001520 Large for gestational age
Displaying all 7 entries
Disease ID Disease Name
OMIM:602485
  • hyperinsulinism due to glucokinase deficiency
ORPHA:552
  • maturity-onset diabetes of the young
OMIM:606176
  • permanent neonatal diabetes mellitus 1
ORPHA:79299
  • hyperinsulinism due to glucokinase deficiency
ORPHA:99885
  • permanent neonatal diabetes mellitus
OMIM:125851
  • maturity-onset diabetes of the young type 2
OMIM:125853
  • type 2 diabetes mellitus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024