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large tumor suppressor kinase 2

Summary

Gene Symbol

LATS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

26524

PubChem

26524

Alliance of Genome Resources

HGNC:6515

Annotation

Keyword

3D-structure
ATP-binding
Cytoskeleton
Magnesium
Metal-binding
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Tumor suppressor

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NRM7	Kinase phosphorylated during mitosis protein Large tumor suppressor homolog 2 Serine/threonine-protein kinase kpm Warts-like kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
G1/S transition of mitotic cell cycle	IDA	12853976
G1/S transition of mitotic cell cycle	IBA
inner cell mass cell fate commitment	IEA
inner cell mass cellular morphogenesis	IEA
chromatin remodeling	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

hormone-mediated signaling pathway

intracellular signal transduction

hippo signaling

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

cell fate commitment [inference]

inner cell mass cell fate commitment

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

inner cell mass cellular morphogenesis

embryonic morphogenesis [inference]

inner cell mass cellular morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

cell fate commitment [inference]

inner cell mass cell fate commitment

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of organ growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cell cycle [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of organ growth

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

hormone-mediated signaling pathway

intracellular signal transduction

hippo signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cell cycle [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of NLRP3 inflammasome complex assembly

regulation of cell cycle [inference]

negative regulation of cell cycle [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of multicellular organismal process [inference]

regulation of organ growth

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
spindle pole	IDA	12853976
spindle pole	IBA
nucleus	NAS	10673337
nucleus	IDA	10673337
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	TAS
protein serine/threonine kinase activity	IDA	10871863 30865227 35429439 39173637
protein serine/threonine kinase activity	IBA
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine/threonine-protein kinase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
I: Lipid transport and metabolism

Displaying **all 9** entries
Gene Ontology
ATP binding
G1/S transition of mitotic cell cycle
hippo signaling
kinase activity
nucleotide binding
phosphorylation
positive regulation of apoptotic process
regulation of organ growth
transferase activity

Displaying **all 7** entries
InterPro
AGC-kinase, C-terminal
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site
UBA-like superfamily
Ubiquitin-associated domain

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9113	FB:FBgn0011739
Drosophila melanogaster	16798	FB:FBgn0011739
Xenopus tropicalis	26524	Xenbase:XB-GENE-994907
Mus musculus	50523		MOUSE12391
Rattus norvegicus	305922		RATNO10200
Pan troglodytes	452466		PANTR07411
Canis lupus familiaris	477343		CANLF09876
Bos taurus	508208		BOVIN03899
Danio rerio	567674		DANRE44291
Macaca mulatta	699957		MACMU17008

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements