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piccolo (presynaptic cytomatrix protein)

Summary

Gene Symbol

Pclo

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

26875

PubChem

26875

Alliance of Genome Resources

MGI:1349390

Annotation

Keyword

Alternative splicing
Calcium/phospholipid-binding
Cell projection
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Synapse
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9QYX7	Aczonin Brain-derived HLMN protein Multidomain presynaptic cytomatrix protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
regulation of exocytosis	IDA	12401793
maintenance of presynaptic active zone structure	IEA
presynaptic actin cytoskeleton organization	EXP IDA IMP	21976510
synaptic vesicle clustering	IDA IMP	20332206
presynapse to nucleus signaling pathway

GO Hierarchy

biological process

cellular process [inference]

vesicle targeting [inference]

synaptic vesicle targeting

signal transduction [inference]

presynaptic signal transduction [inference]

presynapse to nucleus signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to cell junction [inference]

protein localization to synapse

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

actin cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

presynaptic cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

cellular component assembly [inference]

presynaptic active zone assembly

regulation of cellular component size [inference]

regulation of vesicle size [inference]

regulation of endosome size

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

synapse organization

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

presynaptic active zone organization [inference]

exocytic process [inference]

synaptic vesicle targeting

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to cell junction [inference]

protein localization to synapse

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to cell junction [inference]

protein localization to synapse

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis

positive regulation of transport [inference]

positive regulation of synaptic vesicle recycling

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle recycling

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of synaptic vesicle recycling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential

regulation of cellular process [inference]

signal transduction [inference]

presynaptic signal transduction [inference]

presynapse to nucleus signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of vesicle size [inference]

regulation of endosome size

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
presynaptic active zone cytoplasmic component	ISO
inhibitory synapse	ISO
parallel fiber to Purkinje cell synapse	ISO
rod spherule	ISO
postsynaptic density	IDA	17114649

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cell junction [inference]

synapse

neuromuscular junction

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

site of polarized growth [inference]

growth cone

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cytoskeleton of presynaptic active zone

presynaptic cytoskeleton [inference]

cytoskeleton of presynaptic active zone

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cytoskeleton of presynaptic active zone

presynaptic cytoskeleton [inference]

cytoskeleton of presynaptic active zone

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

cone cell pedicle

presynapse [inference]

terminal bouton

axon terminus [inference]

cone cell pedicle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12401793 19812333
structural constituent of presynaptic active zone	IBA IDA IMP	26793095
transcription corepressor binding	ISO
calcium-dependent phospholipid binding	ISO ISS
profilin binding	IDA	10508862

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of presynaptic active zone

binding [inference]

protein binding

profilin binding

transcription factor binding [inference]

transcription coregulator binding [inference]

transcription corepressor binding

lipid binding [inference]

phospholipid binding [inference]

calcium-dependent phospholipid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

protein piccolo

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
presynaptic active zone assembly
protein localization to synapse
structural constituent of presynaptic active zone

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060272	pontocerebellar hypoplasia type 3	Alliance of Genome Resources
DOID:1595	melancholic depression	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	27445		HGNC:13406	HUMAN89626
Rattus norvegicus	56768	10116_1:001d1f	RGD:69406	RATNO30495
Caenorhabditis elegans	177539		WB:WBGene00018468
Pan troglodytes	463505			PANTR40649
Canis lupus familiaris	483388			CANLF05579
Danio rerio	565842		ZFIN:ZDB-GENE-030131-8100
Macaca mulatta	708685			MACMU32172
Ornithorhynchus anatinus	100074697			ORNAN05144
Danio rerio	100148002		ZFIN:ZDB-GENE-030131-8115
Taeniopygia guttata	100217797			TAEGU08619