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aquaporin 4

Summary

Gene Symbol

AQP4

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281008
PubChem: 281008

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O77750	Mercurial-insensitive water channel WCH4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cerebrospinal fluid circulation
intracellular water homeostasis
multicellular organismal-level water homeostasis
transmembrane transport	IEA	22301074
water transport

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cerebrospinal fluid circulation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

fluid transport [inference]

water transport

transmembrane transport

organic substance transport [inference]

water transport

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sarcolemma
plasma membrane	IEA	30032202
extracellular region
astrocyte end-foot
endosome membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot

Displaying 1 entry
GO Term	Evidence Code	PMID
water channel activity	IEA	30032202

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

water channel activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aquaporin A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
water channel activity

Displaying **all 4** entries
InterPro
Aquaporin transporter
Aquaporin-like
Major intrinsic protein, conserved site
Major intrinsic protein

Ortholog

Displaying entries **111 - 120** of **122** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Balaenoptera musculus	118880227	9771_0:00348f	BALMU02609
Oryx dammah	120881162	59534_0:0036f4
Cyprinus carpio carpio	122148958		CYPCA105472
Panthera leo	122203499		PANLE01048
Cervus canadensis	122425575	1574408_0:0040b3
Cervus elaphus	122684803	9860_0:004d44
Ursus americanus	123782066		URSAM03834
Phacochoerus africanus	125134559	41426_0:0028f7
Budorcas taxicolor	128067494	37181_0:0046b4
Moschus berezovskii	129549715	68408_0:00180e

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OrthoDB (Group)

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Acknowledgements