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aquaporin 4

Summary

Gene Symbol

AQP4

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281008
PubChem: 281008

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O77750	Mercurial-insensitive water channel WCH4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cerebrospinal fluid circulation
intracellular water homeostasis
multicellular organismal-level water homeostasis
transmembrane transport	IEA	22301074
water transport

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cerebrospinal fluid circulation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

fluid transport [inference]

water transport

transmembrane transport

organic substance transport [inference]

water transport

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sarcolemma
plasma membrane	IEA	30032202
extracellular region
astrocyte end-foot
endosome membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot

Displaying 1 entry
GO Term	Evidence Code	PMID
water channel activity	IEA	30032202

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

water channel activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aquaporin A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
water channel activity

Displaying **all 4** entries
InterPro
Aquaporin transporter
Aquaporin-like
Major intrinsic protein, conserved site
Major intrinsic protein

Ortholog

Displaying entries **81 - 90** of **122** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pygocentrus nattereri	108442721		PYGNA28323
Rhinopithecus bieti	108520539		RHIBE31791
Cyprinus carpio carpio	109113392		CYPCA83114
Crocodylus porosus	109318196		CROPO01941
Hippocampus comes	109521284		HIPCM03759
Bos indicus	109577908	9915_0:004256
Phascolarctos cinereus	110195804		PHACI16526
Seriola dumerili	111231044		SERDU13926
Amphiprion ocellaris	111580249		AMPOC27399
Oryzias melastigma	112147110		ORYME25382

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OrthoDB (Group)

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Acknowledgements