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calcium sensing receptor

Summary

Gene Symbol

CASR

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281038
PubChem: 281038

Annotation

Keyword

Calcium
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P35384	Parathyroid cell calcium-sensing receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ossification
detection of calcium ion	IEA	30032202
calcium ion transport
intracellular calcium ion homeostasis	IEA	30032202
G protein-coupled receptor signaling pathway	IEA	22301074 30032202

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

multicellular organismal process [inference]

ossification

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

response to chemical [inference]

response to organic substance [inference]

response to calcium ion [inference]

detection of calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

detection of calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

detection of calcium ion

response to salt [inference]

response to calcium ion [inference]

detection of calcium ion

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of calcium ion

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
axon terminus

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA	22301074 30032202
calcium ion binding	IEA	30032202
amino acid binding
protein homodimerization activity

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, extracellular calcium-sensing receptor-related
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Ortholog

Displaying entries **1 - 10** of **101** in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	846	HUMAN71860
Mus musculus	12374	MOUSE19497
Rattus norvegicus	24247	RATNO04089
Pan troglodytes	460628	PANTR31977
Canis lupus familiaris	488007	CANLF13351
Danio rerio	560607	DANRE37362
Macaca mulatta	714441	MACMU27925
Monodelphis domestica	100018274	MONDO22815
Equus caballus	100034084	HORSE14350
Ornithorhynchus anatinus	100085595	ORNAN07720