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glutathione peroxidase 1

Summary

Gene Symbol

GPX1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281209
KEGG Gene ID: bta:281209
PubChem: 281209

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Glycation
Lipid metabolism
Mitochondrion
Peroxidase
Phosphoprotein
Reference proteome
Selenocysteine

Proteins

Displaying 1 entry
UniProt	Protein Name
P00435	Cellular glutathione peroxidase Phospholipid-hydroperoxide glutathione peroxidase GPX1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
arachidonic acid metabolic process
response to hydrogen peroxide	IEA	30032202
hydrogen peroxide catabolic process	IEA	30032202
positive regulation of supramolecular fiber organization
glutathione metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

glutathione metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide

response to inorganic substance [inference]

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization

regulation of supramolecular fiber organization [inference]

positive regulation of supramolecular fiber organization

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phospholipid-hydroperoxide glutathione peroxidase activity
glutathione peroxidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione peroxidase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
cellular oxidant detoxification
oxidoreductase activity
response to oxidative stress

Displaying **all 3** entries
InterPro
Glutathione peroxidase conserved site
Glutathione peroxidase
Thioredoxin-like superfamily

KEGG BRITE Database

Orthology

K00432

Name

glutathione peroxidase [EC:1.11.1.9]

References

3408482

Rhea

RHEA:19057

a hydroperoxy polyunsaturated fatty acid + glutathione

a hydroxy polyunsaturated fatty acid + H₂O + glutathione disulfide

Enzyme

1.11.1.12

PMID

RHEA:16833

H₂O₂ + glutathione

H₂O + glutathione disulfide

Enzyme

1.11.1.9

PMID

Ortholog

Displaying entries **41 - 50** of 57 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Bos indicus	109576172	9915_0:003ea0
Bos indicus x Bos taurus	113880580	30522_0:00401e
Monodon monoceros	114908128	40151_0:003497
Sparus aurata	115583664		SPAAU40057
Corvus moneduloides	116449487		CORMO01444
Rhinolophus ferrumequinum	117036661		RHIFE15988
Balaenoptera musculus	118904421	9771_0:002c82
Oryx dammah	120868266	59534_0:00180c
Panthera leo	122214340		PANLE23117
Cervus canadensis	122424961	1574408_0:003e6b