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beta-1,4-galactosyltransferase 1

Summary

Gene Symbol

B4GALT1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281781
KEGG Gene ID: bta:281781
PubChem: 281781

Annotation

Keyword

3D-structure
Alternative initiation
Cell membrane
Cell projection
Direct protein sequencing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P08037	Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Lactose synthase A protein N-acetyllactosamine synthase Nal synthase Neolactotriaosylceramide beta-1,4-galactosyltransferase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA	22301074 30032202
lactose biosynthetic process
protein N-linked glycosylation	IEA	30032202
lipid metabolic process
oligosaccharide biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of circulating fibrinogen levels [inference]

positive regulation of circulating fibrinogen levels

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
Golgi trans cisterna
extracellular space
Golgi apparatus	IEA	30032202
external side of plasma membrane
basolateral plasma membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi trans cisterna

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IEA	30032202
N-acetyllactosamine synthase activity
lactose synthase activity
cytoskeletal protein binding	IEA	30032202
manganese ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding

tubulin binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Beta-1,4-galactosyltransferase 4

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
galactosyltransferase activity
glycosylation
metal ion binding
transferase activity

Displaying **all 4** entries
InterPro
Beta-1,4-galactosyltransferase
Galactosyltransferase, C-terminal
Galactosyltransferase, N-terminal
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K07966

Name

beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]

References

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07617	2.4.1.-	G00033MO	G64973KT
R06033	2.4.1.-	G70874WW	G84034JH
R05989	2.4.1.38	G80858MF	G78059CC
R05977	2.4.1.- 2.4.1.275	G06239NA	G58896AZ

Rhea

RHEA:31499

a β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP-α-D-galactose

H⁺ + a neolactoside nLc4Cer(d18:1(4E)) + UDP

Enzyme

2.4.1.275

PMID

RHEA:22932

an N-acetyl-β-D-glucosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.38

PMID

RHEA:12404

D-glucose + UDP-α-D-galactose

H⁺ + lactose + UDP

Enzyme

2.4.1.22

PMID

RHEA:17745

N-acetyl-D-glucosamine + UDP-α-D-galactose

H⁺ + UDP + β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine

Enzyme

2.4.1.90

PMID

Ortholog

Displaying entries **11 - 20** of 84 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100385157	CALJA18761
Pongo abelii	100438031	PONAB36354
Ailuropoda melanoleuca	100477164	AILME05607
Sus scrofa	100511655	PIGXX00469
Pan troglodytes	100613700	PANTR43800
Ovis aries	100620048	SHEEP08882
Loxodonta africana	100659897	LOXAF17408
Oreochromis niloticus	100692426	ORENI47747
Oreochromis niloticus	100692970	ORENI47747
Capra hircus	100860927	CAPHI29365

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements