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F-box protein 43

Summary

Gene Symbol

FBXO43

Organism

Homo sapiens (human)

External Links

NCBI Gene

286151

PubChem

286151

Alliance of Genome Resources

HGNC:28521

Annotation

Keyword

Disease variant
Meiosis
Phosphoprotein
Reference proteome
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4G163	Endogenous meiotic inhibitor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of cell cycle process	IMP	34052850
meiotic cell cycle	IEA
protein ubiquitination	IEA
negative regulation of meiotic nuclear division	IBA
regulation of mitotic nuclear division	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

reproductive process [inference]

meiotic cell cycle

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of reproductive process [inference]

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

regulation of nuclear division [inference]

regulation of mitotic nuclear division

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division

regulation of cell cycle process [inference]

regulation of mitotic nuclear division

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of cell cycle [inference]

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

negative regulation of reproductive process [inference]

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 34595750
zinc ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
metal ion binding
negative regulation of cell cycle process
negative regulation of meiotic nuclear division
protein ubiquitination
regulation of mitotic nuclear division

Displaying **all 3** entries
InterPro
F-box domain
F-box only protein 5/43
Zinc finger ZBR-type domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112353	spermatogenic failure 64	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 59 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Taeniopygia guttata	100222049			TAEGU17328
Xenopus tropicalis	100379689		Xenbase:XB-GENE-951946
Callithrix jacchus	100415427			CALJA13390
Pongo abelii	100454813	9601_0:002439		PONAB34357
Ailuropoda melanoleuca	100464298			AILME18086
Anolis carolinensis	100560481			ANOCA14236
Nomascus leucogenys	100592257			NOMLE11974
Loxodonta africana	100671647			LOXAF16449
Cavia porcellus	100732450			CAVPO00056
Sarcophilus harrisii	100916087			SARHA06481