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F-box protein 43

Summary

Gene Symbol

FBXO43

Organism

Homo sapiens (human)

External Links

NCBI Gene

286151

PubChem

286151

Alliance of Genome Resources

HGNC:28521

Annotation

Keyword

Disease variant
Meiosis
Phosphoprotein
Reference proteome
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4G163	Endogenous meiotic inhibitor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of cell cycle process	IMP	34052850
meiotic cell cycle	IEA
protein ubiquitination	IEA
negative regulation of meiotic nuclear division	IBA
regulation of mitotic nuclear division	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

reproductive process [inference]

meiotic cell cycle

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of reproductive process [inference]

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

regulation of nuclear division [inference]

regulation of mitotic nuclear division

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of meiotic nuclear division

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division

regulation of cell cycle process [inference]

regulation of mitotic nuclear division

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of cell cycle [inference]

negative regulation of cell cycle process

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

negative regulation of meiotic nuclear division

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

negative regulation of reproductive process [inference]

negative regulation of meiotic cell cycle [inference]

negative regulation of meiotic nuclear division

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 34595750
zinc ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
metal ion binding
negative regulation of cell cycle process
negative regulation of meiotic nuclear division
protein ubiquitination
regulation of mitotic nuclear division

Displaying **all 3** entries
InterPro
F-box domain
F-box only protein 5/43
Zinc finger ZBR-type domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112353	spermatogenic failure 64	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33959		FB:FBgn0017551
Mus musculus	78803		MGI:1926053	MOUSE15935
Rattus norvegicus	315034		RGD:1310225	RATNO38432
Danio rerio	393403		ZFIN:ZDB-GENE-040426-1645
Pan troglodytes	464313	9598_0:0026c3		PANTR43032
Canis lupus familiaris	481982			CANLF03110
Bos taurus	540145			BOVIN06124
Xenopus laevis	733440		Xenbase:XB-GENE-17330026
Monodelphis domestica	100030521			MONDO19983
Xenopus laevis	100101275		Xenbase:XB-GENE-951950