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glutathione peroxidase 3

Summary

Gene Symbol

GPX3

Aliases

selenoprotein GPX3

Organism

Homo sapiens (human)

External Links

NCBI Gene

2878

HGNC

4555

KEGG Gene ID

hsa:2878

PubChem

2878

Alliance of Genome Resources

HGNC:4555

Annotation

Keyword

3D-structure
Direct protein sequencing
Peroxidase
Reference proteome
Secreted
Selenocysteine
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P22352	Extracellular glutathione peroxidase Plasma glutathione peroxidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
response to lipid hydroperoxide	TAS	2491950
hydrogen peroxide catabolic process	TAS	2491950
hydrogen peroxide catabolic process	IBA
cellular oxidant detoxification	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to hydroperoxide [inference]

response to lipid hydroperoxide

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to lipid hydroperoxide

response to oxygen-containing compound [inference]

response to hydroperoxide [inference]

response to lipid hydroperoxide

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	1897960
extracellular space	IBA
extracellular exosome	HDA	19199708 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glutathione peroxidase activity	IDA	1897960 3693360
glutathione peroxidase activity	IBA
protein binding	IPI	25416956
selenium binding	IDA	2491950 3693360
selenium binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

glutathione peroxidase activity

binding [inference]

protein binding

identical protein binding

selenium binding

antioxidant activity [inference]

peroxidase activity [inference]

glutathione peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione peroxidase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
cellular oxidant detoxification
oxidoreductase activity
response to oxidative stress

Displaying **all 3** entries
InterPro
Glutathione peroxidase conserved site
Glutathione peroxidase
Thioredoxin-like superfamily

KEGG BRITE Database

Orthology

K00432

Name

glutathione peroxidase [EC:1.11.1.9]

References

3408482

Rhea

RHEA:16833

H₂O₂ + glutathione

H₂O + glutathione disulfide

Enzyme

1.11.1.9

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:4914	esophagus adenocarcinoma	Alliance of Genome Resources
DOID:5041	esophageal cancer	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:7941	Barrett's adenocarcinoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001191
Gene Name: glutathione peroxidase 3 (plasma)

Ortholog

Displaying entries **31 - 40** of 48 in total

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Species	Gene ID	Orthologous MAtrix
Pteropus vampyrus	105299460	PTEVA14121
Macaca nemestrina	105466859	MACNE08005
Mandrillus leucophaeus	105543416	MANLE16355
Cercocebus atys	105589898	CERAT28192
Aotus nancymaae	105714085	AOTNA00074
Propithecus coquereli	105821573	PROCO11557
Microcebus murinus	105858033	MICMU13058
Dipodomys ordii	105998951	DIPOR21978
Salmo salar	106612297	SALSA140059
Equus asinus asinus	106826858	EQUAS13676

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements