GlyCosmos Portal

Annotation

Keyword

Collagen
Dioxygenase
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Iron
Manganese
Membrane
Metal-binding
Multifunctional enzyme
Reference proteome
Secreted
Signal
Vitamin C

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6J056
Q5U367

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
hydroxylysine biosynthetic process	IEA ISO
collagen metabolic process	IEA ISO
vasodilation	IEA ISO
collagen fibril organization	IBA IEA ISO
peptidyl-lysine hydroxylation	IEA ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

collagen metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

basement membrane assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

supramolecular fiber organization [inference]

collagen fibril organization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis [inference]

endothelial cell morphogenesis

animal organ morphogenesis [inference]

lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epidermis morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

epithelium development [inference]

neural tube development

tube development [inference]

neural tube development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA ISO ISS
extracellular space	IBA IEA ISO ISS
rough endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
procollagen galactosyltransferase activity	IEA ISO ISS
procollagen-lysine 5-dioxygenase activity	IBA IEA ISO ISS
procollagen glucosyltransferase activity	IBA IEA ISO ISS
metal ion binding	ISO
small molecule binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

procollagen galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

procollagen galactosyltransferase activity

glucosyltransferase activity [inference]

procollagen glucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen glucosyltransferase activity
procollagen-lysine 5-dioxygenase activity

Displaying **all 5** entries
InterPro
Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain
Nucleotide-diphospho-sugar transferases
Oxoglutarate/iron-dependent dioxygenase
Procollagen-lysine 5-dioxygenase, conserved site
Prolyl 4-hydroxylase, alpha subunit

KEGG BRITE Database

Orthology

K13646

Name

lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]

References

Rhea

RHEA:16569

O₂ + 2-oxoglutarate

CO₂ + succinate

Enzyme

1.14.11.4

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8985		HGNC:9083	HUMAN90460
Mus musculus	26433	10090_1:0018eb	MGI:1347008	MOUSE47276
Drosophila melanogaster	39265		FB:FBgn0036147
Caenorhabditis elegans	174564		WB:WBGene00002497
Pan troglodytes	463618			PANTR41006
Canis lupus familiaris	479730			CANLF16186
Bos taurus	514996			BOVIN20831
Danio rerio	556077		ZFIN:ZDB-GENE-021031-4	DANRE24743
Macaca mulatta	714283			MACMU31302
Xenopus tropicalis	734090		Xenbase:XB-GENE-5916631

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements