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ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Summary

Gene Symbol

Aliases

A3GALNT
A3GALT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

GGDB ID

gg085
gg200

HGNC

mRNA

map

9q34.1-q34.2

Protein

OMIM

110300

KEGG Gene ID

hsa:28

PubChem

Alliance of Genome Resources

HGNC:79

Annotation

Keyword

3D-structure
Blood group antigen
Direct protein sequencing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A089QDC1
P16442	Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-galactosyltransferase Histo-blood group A transferase Histo-blood group B transferase NAGAT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
lipid glycosylation	IBA
protein glycosylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
vesicle	IBA
extracellular region	TAS
Golgi apparatus	IBA
Golgi cisterna membrane	IEA
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
antigen binding	IMP	12198488
manganese ion binding	IMP	12198488
fucosylgalactoside 3-alpha-galactosyltransferase activity	IEA
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IBA
nucleotide binding	IMP	12198488

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

binding [inference]

antigen binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg200

Gene Symbol

Reactions

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
UDP-Gal	G00068MO	G47548GA	2104827
UDP-Gal	G64904FE	G14646AF

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Donor	Acceptor	Product	Reference
UDP-Gal	G62735WZ	G29100FF	2433836 6782678
UDP-GalNAc	G44060QH	G62735WZ	2433836
UDP-Gal	G94435QH	G88313DY
UDP-GalNAc	G53542OI	G49277CJ
UDP-Gal	G94514IB	G10706IL
UDP-GalNAc	G47180UC	G05106AU
UDP-Gal	G14380OJ	G43946PN
UDP-GalNAc	G14380OJ	G89026DU
UDP-Gal	G00068MO	G47548GA	2104827
UDP-GalNAc	G64904FE	G56734EJ

Displaying **all 6** entries
Donor	Acceptor	Product	Reference
UDP-GalNAc	G19749DC
UDP-Gal	G19749DC
UDP-Gal	G32723SL
UDP-GalNAc	G32723SL
UDP-Gal	G11647UD
UDP-GalNAc	G11647UD

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_075582	NM_023094
Mus musculus	NP_109643	NM_030718

KEGG BRITE Database

Orthology

K00709

Name

histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]

References

12180981

Reactions

Displaying **all 9** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06190	2.4.1.37	G66427ZQ	G47614ZH
R06187	2.4.1.40	G13636IT	G96538JO
R13171	2.4.1.40	G98465JN	G37830TX
R06193	2.4.1.40	G66427ZQ	G46461VY
R06191	2.4.1.40	G59724US	G20578GS
R06168	2.4.1.37	G00050MO	G63238VS
R06197	2.4.1.40	G58990QD	G51661GQ
R06167	2.4.1.40	G00050MO	G82858KU
R06029	2.4.1.37	G13636IT	G77593JU

Rhea

RHEA:14349

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-α-D-galactose

an α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.37

PMID

RHEA:19021

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-N-acetyl-α-D-galactosamine

an N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.40

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of **435** in total

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DO ID	Disease Name	Source
DOID:0060573	von Willebrand's disease 1	DisGeNET
DOID:0060651	MYH-9 related disease	DisGeNET
DOID:0060668	anencephaly	DisGeNET
DOID:0060680	pigment dispersion syndrome	DisGeNET
DOID:0060692	platelet-type bleeding disorder 8	DisGeNET
DOID:0070226	progressive familial intrahepatic cholestasis 1	DisGeNET
DOID:0070322	childhood hepatocellular carcinoma	DisGeNET
DOID:0070328	adult hepatocellular carcinoma	DisGeNET
DOID:0080016	spina bifida	DisGeNET
DOID:0080144	childhood acute lymphocytic leukemia	DisGeNET

PubChem Disease

MedGen Diseases

ABO blood group system

OMIM Phenotypes

BLOOD GROUP, ABO SYSTEM

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006775
Gene Name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	387303	ZFIN:ZDB-GENE-031204-4
Danio rerio	393300	ZFIN:ZDB-GENE-040426-1117
Danio rerio	447881	ZFIN:ZDB-GENE-040912-46
Danio rerio	563897	ZFIN:ZDB-GENE-080402-11
Danio rerio	566487	ZFIN:ZDB-GENE-060531-71
Danio rerio	100005565	ZFIN:ZDB-GENE-060531-59
Danio rerio	100005704	ZFIN:ZDB-GENE-060531-70
Xenopus laevis	495825	Xenbase:XB-GENE-5962623
Xenopus laevis	108698211	Xenbase:XB-GENE-6488967
Xenopus laevis	108698863	Xenbase:XB-GENE-17341092

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements