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ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Summary

Gene Symbol

Aliases

A3GALNT
A3GALT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

GGDB ID

gg085
gg200

HGNC

mRNA

map

9q34.1-q34.2

Protein

OMIM

110300

KEGG Gene ID

hsa:28

PubChem

Alliance of Genome Resources

HGNC:79

Annotation

Keyword

3D-structure
Blood group antigen
Direct protein sequencing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A089QDC1
P16442	Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-galactosyltransferase Histo-blood group A transferase Histo-blood group B transferase NAGAT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein glycosylation	IEA
carbohydrate metabolic process	IEA
lipid glycosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA
extracellular region	TAS
vesicle	IBA
Golgi cisterna membrane	IEA
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IBA
fucosylgalactoside 3-alpha-galactosyltransferase activity	IEA
manganese ion binding	IMP	12198488
antigen binding	IMP	12198488
nucleotide binding	IMP	12198488

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

binding [inference]

antigen binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A transferase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hexosyltransferase activity
lipid glycosylation
metal ion binding
transferase activity

Displaying **all 2** entries
InterPro
Glycosyl transferase, family 6
Nucleotide-diphospho-sugar transferases

GlycoGene Database (GGDB)

GGDB ID

gg200

Gene Symbol

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G00068MO	R	G47548GA	R	2104827
UDP-Gal	G64904FE	O-glycan Synthesis	G14646AF	O-glycan Synthesis

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G14380OJ	O-glycan Synthesis	G43946PN	O-glycan Synthesis
UDP-Gal	G00068MO	R	G47548GA	R	2104827
UDP-Gal	G64904FE	O-glycan Synthesis	G14646AF	O-glycan Synthesis
UDP-Gal	G16673GG	R	G19620VP	R	2433836 6782678
UDP-Gal	G38351JR	O-glycan Synthesis	G28599FB	O-glycan Synthesis

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GalNAc	G11647UD	O-glycan Synthesis

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_075582	NM_023094
Mus musculus	NP_109643	NM_030718

KEGG BRITE Database

Orthology

K00709

Name

histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]

References

12180981

Reactions

Displaying **all 9** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06191	2.4.1.40	G59724US	G20578GS
R06193	2.4.1.40	G66427ZQ	G46461VY
R06029	2.4.1.37	G13636IT	G77593JU
R06197	2.4.1.40	G58990QD	G51661GQ
R06187	2.4.1.40	G13636IT	G96538JO
R06167	2.4.1.40	G00050MO	G82858KU
R06190	2.4.1.37	G66427ZQ	G47614ZH
R13171	2.4.1.40	G98465JN	G37830TX
R06168	2.4.1.37	G00050MO	G63238VS

Rhea

RHEA:19021

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-N-acetyl-α-D-galactosamine

an N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.40

PMID

RHEA:14349

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-α-D-galactose

an α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.37

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1240	leukemia	Alliance of Genome Resources
DOID:13406	pulmonary sarcoidosis	Alliance of Genome Resources
DOID:14067	Plasmodium falciparum malaria	Alliance of Genome Resources
DOID:1496	echinococcosis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2237	hepatitis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

PubChem Disease

MedGen Diseases

ABO blood group system

OMIM Phenotypes

BLOOD GROUP, ABO SYSTEM

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006775
Gene Name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

Ortholog

Displaying entries **21 - 30** of 33 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Pan paniscus	100970130	9597_0:00271c		PANPA40563
Gorilla gorilla gorilla	101125978	9595_0:002c6f
Jaculus jaculus	101599636			JACJA05587
Chlorocebus sabaeus	103239700			CHLSB02930
Carlito syrichta	103250932			CARSF19150
Nannospalax galili	103740691			NANGA26747
Mandrillus leucophaeus	105542951			MANLE21116
Cercocebus atys	105594179			CERAT42206
Rhinopithecus bieti	108513461			RHIBE14653
Xenopus laevis	108698211		Xenbase:XB-GENE-6488967

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements