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ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

Summary

Gene Symbol

Uqcrfs1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

291103

PubChem

291103

Alliance of Genome Resources

RGD:628838

Annotation

Keyword

2Fe-2S
Direct protein sequencing
Disulfide bond
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Respiratory chain
Transit peptide
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6J7M2
P20788	Complex III subunit 5 Cytochrome b-c1 complex subunit 5 Liver regeneration-related protein LRRGT00195 Rieske iron-sulfur protein Rieske protein UQCRFS1 Ubiquinol-cytochrome c reductase iron-sulfur subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrial electron transport, ubiquinol to cytochrome c	IBA
mitochondrial respiratory chain complex III assembly	ISO
response to xenobiotic stimulus	IEP	15730530
response to hormone	IEP	2776768
respiratory electron transport chain	ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex III assembly [inference]

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex III assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex III assembly [inference]

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex III assembly

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

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GO Term	Evidence Code	PMID
mitochondrial membrane	IDA	16023995
mitochondrial respiratory chain complex IV
mitochondrial inner membrane	IEA
respiratory chain complex III	IBA IDA ISO TAS	12794875 2538119
mitochondrion	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

respiratory chain complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

respiratory chain complex IV [inference]

mitochondrial respiratory chain complex IV

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

respiratory chain complex IV [inference]

mitochondrial respiratory chain complex IV

oxidoreductase complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
oxidoreductase activity	IBA
protein-containing complex binding	IDA	19166612
metal ion binding	IEA
2 iron, 2 sulfur cluster binding	IEA
ubiquinol-cytochrome-c reductase activity	TAS	2538119

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

electron transfer activity [inference]

ubiquinol-cytochrome-c reductase activity

oxidoreductase activity, acting on diphenols and related substances as donors [inference]

ubiquinol-cytochrome-c reductase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

2 iron, 2 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cytochrome b-c1 complex subunit Rieske, mitochondrial

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 5** entries
Gene Ontology
2 iron, 2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
mitochondrial electron transport, ubiquinol to cytochrome c
oxidoreductase activity

Displaying **all 9** entries
InterPro
Cytochrome b-c1 complex subunit Rieske, transmembrane domain
Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily
Globular protein, non-globular alpha/beta subunit
Rieske [2Fe-2S] iron-sulphur domain superfamily
Rieske [2Fe-2S] iron-sulphur domain
Rieske iron-sulphur protein, C-terminal
Rieske iron-sulphur protein
Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal
Ubiquinol-cytochrome c reductase, iron-sulphur subunit

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
respiratory chain complex III	PMID:12794875
mitochondrial membrane	PMID:16023995

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111139	mitochondrial complex III deficiency	Alliance of Genome Resources
DOID:700	mitochondrial metabolism disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **130** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7386		HGNC:12587	HUMAN42379
Drosophila melanogaster	44390		FB:FBgn0021906
Mus musculus	66694	10090_1:0040a2	MGI:1913944	MOUSE10869
Caenorhabditis elegans	177609		WB:WBGene00002162
Bos taurus	287020			BOVIN10098
Xenopus tropicalis	394506		Xenbase:XB-GENE-5746219
Danio rerio	406359		ZFIN:ZDB-GENE-040426-2060	DANRE40102
Canis lupus familiaris	476503			CANLF01271
Macaca mulatta	700087			MACMU18786
Macaca mulatta	705178			MACMU18786

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LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements