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ATPase phospholipid transporting 8B1

Summary

Gene Symbol

Atp8b1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

291555

PubChem

291555

Alliance of Genome Resources

RGD:1308488

Annotation

Keyword

ATP-binding
Cell membrane
Cell projection
Coiled coil
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Magnesium
Metal-binding
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8L2QJ69
D4AA47	ATPase class I type 8B member 1 P4-ATPase flippase complex alpha subunit ATP8B1
A6IXP4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
xenobiotic transmembrane transport	ISO
xenobiotic transmembrane transport	IEA
Golgi organization	IBA
sensory perception of sound	ISO
sensory perception of sound	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

organic hydroxy compound metabolic process [inference]

bile acid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

inner ear receptor cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

apical protein localization

transmembrane transport [inference]

xenobiotic transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cranial nerve formation [inference]

vestibulocochlear nerve formation

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

inner ear receptor cell development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

inner ear receptor cell development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

apical protein localization

establishment of localization [inference]

transport [inference]

xenobiotic transport [inference]

xenobiotic transmembrane transport

transmembrane transport [inference]

xenobiotic transmembrane transport

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

phospholipid transport [inference]

aminophospholipid transport

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

organic anion transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organophosphate ester transport [inference]

phospholipid transport [inference]

aminophospholipid transport

aminophospholipid translocation

phospholipid translocation

aminophospholipid translocation

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

nitrogen compound transport [inference]

aminophospholipid transport

aminophospholipid translocation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

apical protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of monoatomic anion transport [inference]

regulation of chloride transport

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of microvillus assembly

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of microvillus assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of microvillus organization [inference]

regulation of microvillus assembly

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of microvillus assembly

regulation of plasma membrane organization

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

aminophospholipid translocation

Displaying entries **6 - 10** of 20 in total

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GO Term	Evidence Code	PMID
trans-Golgi network	IBA
cytosol	ISO
cytosol	IEA
plasma membrane	ISO
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

phospholipid-translocating ATPase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

nuclear body

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
lipid transporter activity	ISO
ATP binding	IEA
aminophospholipid flippase activity	ISO
aminophospholipid flippase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

aminophospholipid flippase activity

phosphatidylserine flippase activity

phosphatidylserine floppase activity

glycerophospholipid flippase activity [inference]

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

aminophospholipid flippase activity

phosphatidylserine flippase activity

glycerophospholipid flippase activity [inference]

floppase activity [inference]

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylglycerol binding [inference]

cardiolipin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

phosphatidylglycerol binding [inference]

cardiolipin binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

aminophospholipid flippase activity

phosphatidylserine flippase activity

glycerophospholipid flippase activity [inference]

floppase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATPase

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
lipid translocation
magnesium ion binding
metal ion binding
nucleotide binding
phospholipid translocation
phospholipid transport

Displaying entries **1 - 10** of 11 in total

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InterPro
HAD superfamily
HAD-like superfamily
P-type ATPase, A domain superfamily
P-type ATPase, C-terminal
P-type ATPase, N-terminal
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site
P-type ATPase, subfamily IV
P-type ATPase, transmembrane domain superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
brush border membrane	PMID:11584374

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5205		HUMAN38710
Saccharomyces cerevisiae S288C	11982	SGD:S000000968
Saccharomyces cerevisiae S288C	23120	SGD:S000000968
Mus musculus	54670		MOUSE23612
Drosophila melanogaster	57198	FB:FBgn0037989
Drosophila melanogaster	79895	FB:FBgn0037989
Xenopus tropicalis	291555	Xenbase:XB-GENE-490143
Pan troglodytes	455439		PANTR16350
Canis lupus familiaris	476190		CANLF00086
Bos taurus	541187		BOVIN19820

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Acknowledgements