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desmoglein 4

Summary

Gene Symbol

Dsg4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

291754

PubChem

291754

Alliance of Genome Resources

RGD:735015

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Disease variant
Glycoprotein
Metal-binding
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6W3B0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA ISO
hair follicle development	ISO
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
BMP signaling pathway	ISO
cell adhesion	TAS	15081105

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure development [inference]

hair follicle development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
desmosome	IBA ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

Displaying 1 entry
GO Term	Evidence Code	PMID
calcium ion binding	IBA IMP	15081105

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

desmoglein-4

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 2** entries
InterPro
Cadherin, Y-type LIR-motif
Cadherin-like

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110703	hypotrichosis 6	Alliance of Genome Resources
DOID:4535	hypotrichosis	Alliance of Genome Resources
DOID:987	alopecia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	16769	10090_1:005135	MGI:2661061
Homo sapiens	147409		HGNC:21307
Danio rerio	100534918		ZFIN:ZDB-GENE-091204-215
Cavia porcellus	100713121	10141_0:00366a
Cricetulus griseus	100762072	10029_0:001cc8
Octodon degus	101576532	10160_0:000269
Jaculus jaculus	101597975	51337_0:004389
Heterocephalus glaber	101703040	10181_0:0023f4
Mesocricetus auratus	101831540	10036_0:003218
Ictidomys tridecemlineatus	101958050	43179_0:000563

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements