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glutamate metabotropic receptor 8

Summary

Gene Symbol

GRM8

Organism

Homo sapiens (human)

External Links

NCBI Gene

2918

PubChem

2918

Alliance of Genome Resources

HGNC:4600

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Isopeptide bond
Reference proteome
Sensory transduction
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O00222

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	11166323
regulation of synaptic transmission, glutamatergic	IBA
G protein-coupled glutamate receptor signaling pathway	IBA
visual perception	TAS	9473604
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IMP	9473604

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glutamate receptor activity	IMP	9473604
group III metabotropic glutamate receptor activity	IBA
G protein-coupled receptor activity	IMP	9473604

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

glutamate receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of synaptic transmission, glutamatergic

Displaying **all 8** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, conserved site
GPCR, family 3, metabotropic glutamate receptor
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Melopsittacus undulatus	101868361	MELUD11484
Ictidomys tridecemlineatus	101965504	ICTTR12134
Chinchilla lanigera	102019168	CHILA17983
Haplochromis burtoni	102293823	HAPBU24191
Myotis lucifugus	102422181	MYOLU06043
Pelodiscus sinensis	102460589	PELSI18300
Vicugna pacos	102534152	VICPA00896
Astyanax mexicanus	103033497	ASTMX05170
Poecilia formosa	103129106	POEFO02114
Chlorocebus sabaeus	103226837	CHLSB09940

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements