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troponin I3, cardiac type

Summary

Gene Symbol

Tnni3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29248

PubChem

29248

Alliance of Genome Resources

RGD:62052

Annotation

Keyword

Acetylation
Actin-binding
Muscle protein
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P23693	Cardiac troponin I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
striated muscle contraction	ISO
regulation of cardiac muscle contraction by calcium ion signaling	ISO
cardiac muscle contraction	IBA IDA IMP ISO	11448842 14551059 9409484
heart development	ISO
regulation of smooth muscle contraction	IMP	16236710

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction

circulatory system process [inference]

heart process [inference]

heart contraction

nervous system process [inference]

nervous system process involved in regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure by ischemic conditions

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction

regulation of smooth muscle contraction

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

negative regulation of ATP-dependent activity

negative regulation of molecular function [inference]

negative regulation of ATP-dependent activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
myofibril	IDA	11448842
cardiac Troponin complex	ISO
cardiac myofibril	ISO
troponin complex	IBA IEA ISO TAS	1886137
sarcomere	IDA ISO	15601779

GO Hierarchy

cellular component

protein-containing complex [inference]

troponin complex

cardiac Troponin complex

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber

myofibril

cardiac myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber

myofibril

cardiac myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber

myofibril

cardiac myofibril

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21569246
actin binding	IEA ISO
actin filament binding	ISO
calcium channel inhibitor activity	ISO
calcium-dependent protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein-containing complex binding [inference]

actin filament binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

ion channel regulator activity [inference]

calcium channel regulator activity [inference]

calcium channel inhibitor activity

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Troponin

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 3** entries
Gene Ontology
actin binding
cardiac muscle contraction
skeletal muscle contraction

Displaying **all 3** entries
InterPro
Troponin I residues 1-32
Troponin domain superfamily
Troponin

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
contractile muscle fiber	PMID:9409484
myofibril	PMID:11448842

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0110313	hypertrophic cardiomyopathy 7	Alliance of Genome Resources
DOID:0110459	dilated cardiomyopathy 1FF	Alliance of Genome Resources
DOID:0110460	dilated cardiomyopathy 2A	Alliance of Genome Resources
DOID:0111425	restrictive cardiomyopathy 1	Alliance of Genome Resources
DOID:114	heart disease	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:299	adenocarcinoma	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 78 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Balaenoptera musculus	118885634		BALMU15967
Arvicola amphibius	119821433	1047088_0:003276
Microtus oregoni	121449614	111838_0:001492
Dipodomys spectabilis	122110728	105255_0:001a99
Panthera leo	122208075		PANLE06828
Ursus americanus	123786948		URSAM08078
Marmota monax	124084032	9995_0:0045c9
Sciurus carolinensis	124966930	30640_0:004582
Perognathus longimembris pacificus	125339094	214514_0:004290
Myodes glareolus	125395536	447135_0:004bfb

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements