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serpin family G member 1

Summary

Gene Symbol

Serping1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

295703

PubChem

295703

Alliance of Genome Resources

RGD:735225

Annotation

Keyword

Complement pathway
Fibrinolysis
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6P734	C1 esterase inhibitor C1-inhibiting factor Serpin G1
A6HMR4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
negative regulation of complement activation, lectin pathway	ISS
negative regulation of complement activation, lectin pathway	ISO
complement activation, classical pathway	IEA
blood coagulation	IEA
negative regulation of peptidase activity

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, classical pathway

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	1505923
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 5** entries
GO Term	Evidence Code	PMID
complement binding	ISO
serine-type endopeptidase inhibitor activity	ISS
serine-type endopeptidase inhibitor activity	ISO
serine-type endopeptidase inhibitor activity	IBA
serine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

complement binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

plasma protease c1 inhibitor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 5** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:1505923

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3068	glioblastoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	12	FB:FBgn0031973
Homo sapiens	710	ZFIN:ZDB-GENE-030131-1262	HUMAN06047
Drosophila melanogaster	866	FB:FBgn0031973
Drosophila melanogaster	5104	FB:FBgn0031973
Drosophila melanogaster	5265	FB:FBgn0031973
Drosophila melanogaster	5267	FB:FBgn0031973
Drosophila melanogaster	5345	FB:FBgn0031973
Drosophila melanogaster	6906	FB:FBgn0031973
Mus musculus	12258	ZFIN:ZDB-GENE-030131-1262	MOUSE34801
Drosophila melanogaster	12401	FB:FBgn0031973

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements