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ABR activator of RhoGEF and GTPase

Summary

Gene Symbol

ABR

Organism

Homo sapiens (human)

External Links

NCBI Gene

29

PubChem

29

Alliance of Genome Resources

HGNC:81

Annotation

Keyword

Alternative splicing
Cell projection
Coiled coil
GTPase activation
Guanine-nucleotide releasing factor
Phosphoprotein
Proteomics identification
Reference proteome
Synapse

Proteins

Displaying **all 6** entries
UniProt	Protein Name
B7Z683
Q6ZT60
B7Z2X0
B7Z7Z1
Q12979
I3L4Y1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of small GTPase mediated signal transduction	TAS
activation of GTPase activity	IDA	7479768
modulation of chemical synaptic transmission	ISS
small GTPase mediated signal transduction	TAS	8262969

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Schaffer collateral - CA1 synapse	ISS
membrane	HDA IBA	19946888
dendritic spine	IEA
axon	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron spine [inference]

dendritic spine

postsynapse [inference]

dendritic spine

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IDA TAS	7479768
protein binding	IPI	20962234
guanyl-nucleotide exchange factor activity	IDA TAS	7479768

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GTPase activator

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Rho GTPase activation protein
Rho GTPase-activating protein domain

Ortholog

Displaying entries **11 - 20** of 91 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	5740235		FB:FBgn0025836
Monodelphis domestica	100011712			MONDO14083
Equus caballus	100059804			HORSE02839
Ornithorhynchus anatinus	100078472			ORNAN09311
Taeniopygia guttata	100220388			TAEGU07764
Callithrix jacchus	100385329			CALJA34061
Pongo abelii	100449816	9601_0:0042c8		PONAB11391
Ailuropoda melanoleuca	100480719			AILME19666
Sus scrofa	100522463			PIGXX03016
Meleagris gallopavo	100545657			MELGA07024