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opsin 4 (melanopsin)

Summary

Gene Symbol

Opn4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

30044

PubChem

30044

Alliance of Genome Resources

MGI:1353425

Annotation

Keyword

Alternative splicing
Biological rhythms
Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Retinal protein
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9QXZ9	Opsin-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IBA
G protein-coupled receptor signaling pathway	IEA
visual perception	IEA
phototransduction	ISO
phototransduction	IMP	12808468

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

rhodopsin mediated signaling pathway

phototransduction

rhodopsin mediated signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

behavior [inference]

visual behavior [inference]

optokinetic behavior

developmental process [inference]

anatomical structure development [inference]

retina development in camera-type eye

anatomical structure regression [inference]

hyaloid vascular plexus regression

locomotion [inference]

taxis [inference]

thermotaxis

rhythmic process

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway

detection of visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

entrainment of circadian clock [inference]

entrainment of circadian clock by photoperiod

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

thermotaxis

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

optokinetic behavior

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway

detection of visible light

photoperiodism [inference]

entrainment of circadian clock by photoperiod

cellular response to light stimulus

rhodopsin mediated signaling pathway

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway

detection of visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway

detection of visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway

detection of visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of circadian rhythm

entrainment of circadian clock [inference]

entrainment of circadian clock by photoperiod

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep [inference]

positive regulation of circadian sleep/wake cycle, sleep

positive regulation of circadian rhythm [inference]

positive regulation of circadian sleep/wake cycle, sleep

positive regulation of biological process [inference]

positive regulation of circadian rhythm [inference]

positive regulation of circadian sleep/wake cycle, sleep

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of circadian sleep/wake cycle, sleep

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

rhodopsin mediated signaling pathway

phototransduction

rhodopsin mediated signaling pathway

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep [inference]

positive regulation of circadian sleep/wake cycle, sleep

positive regulation of behavior [inference]

positive regulation of circadian sleep/wake cycle, sleep

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of circadian sleep/wake cycle, sleep

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
membrane	TAS	10632589
axon	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

sperm head plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

Displaying **all 5** entries
GO Term	Evidence Code	PMID
11-cis retinal binding	ISS
11-cis retinal binding	ISO
G protein-coupled photoreceptor activity	ISO
G protein-coupled photoreceptor activity	IMP	12808468
G protein-coupled photoreceptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinal binding [inference]

11-cis retinal binding

small molecule binding [inference]

vitamin binding [inference]

retinal binding [inference]

11-cis retinal binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled photoreceptor activity

photoreceptor activity [inference]

G protein-coupled photoreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

opsin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular response to light stimulus
photoreceptor activity
phototransduction
visual perception

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Visual pigments (opsins) retinal binding site

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	30044	ZFIN:ZDB-GENE-030314-2
Danio rerio	34615	ZFIN:ZDB-GENE-030314-2
Danio rerio	39887	ZFIN:ZDB-GENE-030314-2
Danio rerio	41889	ZFIN:ZDB-GENE-080415-3
Homo sapiens	42261	HGNC:14449
Danio rerio	42367	ZFIN:ZDB-GENE-080415-3
Danio rerio	42398	ZFIN:ZDB-GENE-030314-2
Homo sapiens	94233		HUMAN02015
Rattus norvegicus	192223	ZFIN:ZDB-GENE-030314-2	RATNO10644
Danio rerio	352918	ZFIN:ZDB-GENE-030314-2