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Guidelines

MIRAGE

rhomboid 5 homolog 1

Summary

Gene Symbol

Rhbdf1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

303008

PubChem

303008

Alliance of Genome Resources

RGD:1305075

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Growth factor binding
Phosphoprotein
Protein transport
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q499S9	Rhomboid family member 1
A6HDB3	Rhomboid family member Rhomboid veinlet-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cell population proliferation	ISS
cell population proliferation	ISO
protein transport	IEA
cell migration	ISS
cell migration	ISO

GO Hierarchy

biological process

cellular process [inference]

cell population proliferation

cell motility [inference]

cell migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi membrane	ISS
Golgi membrane	ISO
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA
growth factor binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

growth factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rhomboid

Functional Category

L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
regulation of epidermal growth factor receptor signaling pathway
regulation of protein secretion
serine-type endopeptidase activity

Displaying **all 3** entries
InterPro
Inactive rhomboid protein 1/2, N-terminal
Peptidase S54, rhomboid domain
Rhomboid-like superfamily

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13650	Xenbase:XB-GENE-6083739	MOUSE03818
Homo sapiens	64285	Xenbase:XB-GENE-6083739	HUMAN25326
Drosophila melanogaster	79651	FB:FBgn0041723
Xenopus tropicalis	131096	Xenbase:XB-GENE-6083739
Xenopus tropicalis	211468	Xenbase:XB-GENE-6083739
Drosophila melanogaster	217344	FB:FBgn0041723
Xenopus tropicalis	246325	Xenbase:XB-GENE-6083739
Xenopus tropicalis	303008	Xenbase:XB-GENE-6083739
Pan troglodytes	453783		PANTR11294
Canis lupus familiaris	490101		CANLF16781

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Last updated: December 8, 2025