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Guidelines

MIRAGE

holocytochrome c synthase

Summary

Gene Symbol

HCCS

Organism

Homo sapiens (human)

External Links

NCBI Gene

3052

PubChem

3052

Alliance of Genome Resources

HGNC:4837

Annotation

Keyword

Disease variant
Heme
Lyase
Microphthalmia
Mitochondrion inner membrane
Myristate
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P53701	Cytochrome c-type heme lyase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
animal organ morphogenesis	TAS	8661044
cytochrome c-heme linkage	IDA	23150584
respiratory electron transport chain	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

macromolecule modification [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

cytochrome c-heme linkage

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

cytochrome c-heme linkage

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA	11827457
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial inner membrane	TAS
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
holocytochrome-c synthase activity	TAS
holocytochrome-c synthase activity	IDA	23150584
holocytochrome-c synthase activity	IBA
protein binding	IPI	28514442 32296183 32814053 33961781
heme binding	IDA	23150584

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-sulfur lyase activity [inference]

holocytochrome-c synthase activity

catalytic activity, acting on a protein [inference]

holocytochrome-c synthase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome C-type heme lyase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
holocytochrome-c synthase activity
lyase activity
metal ion binding

Displaying 1 entry
InterPro
Holocytochrome c/c1 synthase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111808	linear skin defects with multiple congenital anomalies 1	Alliance of Genome Resources
DOID:10629	microphthalmia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 99 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3052	Xenbase:XB-GENE-951278
Mus musculus	15159	Xenbase:XB-GENE-951278	MOUSE66428
Danio rerio	58016		DANRE25716
Rattus norvegicus	317444		RATNO44187
Danio rerio	436771		DANRE29505
Pan troglodytes	465489		PANTR45477
Canis lupus familiaris	480834		CANLF19552
Bos taurus	506250		BOVIN00058
Macaca mulatta	709878		MACMU48031
Monodelphis domestica	100018151		MONDO31782

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025