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Guidelines

MIRAGE

holocytochrome c synthase

Summary

Gene Symbol

HCCS

Organism

Homo sapiens (human)

External Links

NCBI Gene

3052

PubChem

3052

Alliance of Genome Resources

HGNC:4837

JoGo

HCCS

TogoVar

HCCS

Annotation

Keyword

Disease variant
Heme
Lyase
Microphthalmia
Mitochondrion inner membrane
Myristate
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P53701	Cytochrome c-type heme lyase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
animal organ morphogenesis	TAS	8661044
cytochrome c-heme linkage	IDA	23150584
respiratory electron transport chain	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

macromolecule modification [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein-tetrapyrrole linkage [inference]

protein-heme linkage [inference]

cytochrome c-heme linkage

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

cytochrome c-heme linkage

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

cytochrome c-heme linkage

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IDA	23150584

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
holocytochrome-c synthase activity	TAS
holocytochrome-c synthase activity	IDA	23150584
holocytochrome-c synthase activity	IBA
protein binding	IPI	28514442 32296183 32814053 33961781
heme binding	IDA	23150584

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-sulfur lyase activity [inference]

holocytochrome-c synthase activity

catalytic activity, acting on a protein [inference]

holocytochrome-c synthase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111808	linear skin defects with multiple congenital anomalies 1	Alliance of Genome Resources
DOID:10629	microphthalmia	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026