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complement factor H related 1

Summary

Gene Symbol

CFHR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3078

PubChem

3078

Alliance of Genome Resources

HGNC:4888

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Hemolytic uremic syndrome
Reference proteome
Repeat
Secreted
Signal
Sushi

Proteins

Displaying 1 entry
UniProt	Protein Name
Q03591	H factor-like protein 1 H36

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytolysis by host of symbiont cells	IMP	23487775
negative regulation of protein binding	IMP	23487775
complement activation	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

cellular process [inference]

cell killing [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to other organism [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

immune response [inference]

humoral immune response [inference]

complement activation

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding

negative regulation of binding [inference]

negative regulation of protein binding

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein-containing complex	IDA	23487775
extracellular region	TAS
blood microparticle	HDA	22516433
extracellular space	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19528535 22786770 23487775 23728178 27814381 28533443 31273197 33961781
complement component C3b binding	IBA
identical protein binding	IPI	19528535 23487775 23728178 31273197

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080301	atypical hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:0110014	age related macular degeneration 1	Alliance of Genome Resources
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources
DOID:9538	multiple myeloma	Alliance of Genome Resources

Ortholog

Displaying **all 9** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	50702		MGI:2138169	MOUSE30447
Rattus norvegicus	289057		RGD:1310510	RATNO06775
Danio rerio	492777		ZFIN:ZDB-GENE-041114-123
Bos taurus	519737			BOVIN08903
Danio rerio	553297		ZFIN:ZDB-GENE-050208-661
Danio rerio	570905		ZFIN:ZDB-GENE-050208-342
Felis catus	101085428			FELCA36955
Capra hircus	102169690			CAPHI07288
Bos indicus x Bos taurus	113906941			BOBOX06212

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024