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MIRAGE
major histocompatibility complex, class II, DR beta 1
Summary
- Gene Symbol
-
- HLA-DRB1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cytoplasmic vesicle
- Direct protein sequencing
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Isopeptide bond
- Lysosome
- MHC II
- Proteomics identification
- Reference proteome
- Signal
- Transmembrane helix
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P01911 |
|
| Q5Y7D1 |
|
| D7RIH8 |
|
| A0A224MM52 |
|
| X5DNQ0 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of T cell mediated cytotoxicity | ||
| positive regulation of protein phosphorylation | ||
| inflammatory response to antigenic stimulus | ||
| myeloid dendritic cell antigen processing and presentation | ||
| antigen processing and presentation of endogenous peptide antigen via MHC class II |
GO Hierarchy
biological process
immune system process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of leukocyte differentiation [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cell development [inference]
regulation of hemopoiesis [inference]
regulation of leukocyte differentiation [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
regulation of leukocyte differentiation [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cell development [inference]
regulation of hemopoiesis [inference]
regulation of leukocyte differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
positive regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
regulation of leukocyte differentiation [inference]
regulation of biological quality [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| immunological synapse | ||
| extracellular space | ||
| lysosomal membrane | ||
| lysosomal membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| structural constituent of cytoskeleton | ||
| protein binding | ||
| MHC class II protein complex binding | ||
| MHC class II protein complex binding | ||
| polysaccharide binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- HLA class II histocompatibility antigen, DO beta chain
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| adaptive immune response |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| immune response |
| immune system process |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0050168 | autoimmune polyendocrine syndrome type 2 | |
| DOID:0050784 | primary progressive multiple sclerosis | |
| DOID:0050827 | rheumatic heart disease | |
| DOID:0060532 | latex allergy | |
| DOID:0080162 | lupus nephritis | |
| DOID:0080822 | aspirin-induced respiratory disease | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:1024 | leprosy | |
| DOID:10283 | prostate cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3112 | Xenbase:XB-GENE-945971 | ||
| 3115 | Xenbase:XB-GENE-945971 | ||
| 3119 | Xenbase:XB-GENE-945971 | ||
| 3120 | Xenbase:XB-GENE-945971 | ||
| 3123 | Xenbase:XB-GENE-945971 | ||
| 3125 | Xenbase:XB-GENE-945971 | ||
| 3126 | Xenbase:XB-GENE-945971 | ||
| 3127 | Xenbase:XB-GENE-945971 | ||
| 14961 | Xenbase:XB-GENE-945971 | ||
| 14969 | Xenbase:XB-GENE-945971 | MOUSE20174 |
