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ATP binding cassette subfamily G member 2

Summary

Gene Symbol

Abcg2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

312382

PubChem

312382

Alliance of Genome Resources

RGD:631345

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Glycoprotein
Lipid transport
Mitochondrion
Phosphoprotein
Reference proteome
Translocase
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6K137	ATP-binding cassette sub-family G member 2 Urate exporter
Q80W57	ATP-binding cassette sub-family G member 2 Breast cancer resistance protein 1 homolog Urate exporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
lipid transport	IEA
response to iron ion	IEP	15637178
organic anion transport	IDA	15773906
urate transport	IMP	22348008
biotin transport	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

small molecule metabolic process [inference]

urate metabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

cellular detoxification

reproductive process [inference]

multicellular organismal reproductive process [inference]

embryonic process involved in female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

renal system process [inference]

renal tubular secretion [inference]

renal urate salt excretion

excretion [inference]

renal tubular secretion [inference]

renal urate salt excretion

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to organonitrogen compound [inference]

response to folic acid

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to folic acid

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

response to 2,3,7,8-tetrachlorodibenzodioxine

response to lipid [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

response to alcohol

response to ketone [inference]

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

response to inorganic substance [inference]

response to metal ion [inference]

response to iron ion

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to folic acid

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to ketone [inference]

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

vitamin transport [inference]

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

transepithelial transport

organic substance transport [inference]

lipid transport

organic anion transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

biotin transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

biotin transport

nitrogen compound transport [inference]

amide transport [inference]

biotin transport

sulfur compound transport [inference]

biotin transport

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of intestinal absorption

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of intestinal absorption

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption

detoxification [inference]

cellular detoxification

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
plasma membrane	ISO
plasma membrane	IBA
apical plasma membrane	ISO
apical plasma membrane	IDA	18451542 21737571

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

membrane microdomain [inference]

membrane raft

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
cytoskeletal protein binding	IPI	23403943
organic anion transmembrane transporter activity	IDA	15773906
ABC-type xenobiotic transporter activity	ISO
urate transmembrane transporter activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

biotin transmembrane transporter activity

organic anion transmembrane transporter activity

riboflavin transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

biotin transmembrane transporter activity

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

amide transmembrane transporter activity

biotin transmembrane transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

vitamin transmembrane transporter activity [inference]

sulfur compound transmembrane transporter activity [inference]

biotin transmembrane transporter activity

salt transmembrane transporter activity [inference]

binding [inference]

protein binding [inference]

cytoskeletal protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette sub-family G member

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 5** entries
InterPro
AAA+ ATPase domain
ABC transporter family G domain
ABC transporter-like, ATP-binding domain
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
apical plasma membrane	PMID:18451542

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9429	Xenbase:XB-GENE-991895	HUMAN76514
Caenorhabditis elegans	9619	WB:WBGene00015479
Mus musculus	26357	Xenbase:XB-GENE-991895	MOUSE49634
Danio rerio	31271	ZFIN:ZDB-GENE-050517-38
Xenopus tropicalis	39836	Xenbase:XB-GENE-991895
Caenorhabditis elegans	64137	WB:WBGene00015479
Xenopus tropicalis	312382	Xenbase:XB-GENE-991895
Sus scrofa	397073		PIGXX34445
Pan troglodytes	471251		PANTR34094
Canis lupus familiaris	478472		CANLF13058

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements