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Guidelines

MIRAGE

single-strand-selective monofunctional uracil-DNA glycosylase 1

Summary

Gene Symbol

Smug1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

315344

PubChem

315344

Alliance of Genome Resources

RGD:631403

Annotation

Keyword

DNA repair
DNA-binding
Hydrolase
Nucleus
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KCZ5
Q811Q1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
DNA repair	IDA	12718542
base-excision repair	ISO
base-excision repair	IDA	12718543

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
fibrillar center	ISO
fibrillar center	IEA
nucleoplasm	ISO
nucleoplasm	IEA
nucleolus	ISS	12718543

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IDA	12718542
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IBA
DNA binding	IEA
uracil DNA N-glycosylase activity	ISO
uracil DNA N-glycosylase activity	IDA	12718542 12718543

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

single-strand selective uracil DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

single-strand selective uracil DNA N-glycosylase activity

binding [inference]

protein binding [inference]

identical protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

single-strand selective monofunctional uracil DNA glycosylase

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
base-excision repair
hydrolase activity
single-strand selective uracil DNA N-glycosylase activity
uracil DNA N-glycosylase activity

Displaying **all 3** entries
InterPro
Single-strand selective monofunctional uracil DNA glycosylase
Uracil-DNA glycosylase-like domain superfamily
Uracil-DNA glycosylase-like

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23583	Xenbase:XB-GENE-953121	HUMAN13076
Mus musculus	71726	Xenbase:XB-GENE-953121	MOUSE15003
Xenopus tropicalis	315344	Xenbase:XB-GENE-953121
Xenopus tropicalis	399139	Xenbase:XB-GENE-953121
Pan troglodytes	451953		PANTR05694
Canis lupus familiaris	486497		CANLF10710
Bos taurus	539771		BOVIN29037
Macaca mulatta	704743		MACMU03422
Monodelphis domestica	100010844		MONDO34438
Ornithorhynchus anatinus	100091274		ORNAN01317

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025