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8-oxoguanine DNA glycosylase

Summary

Gene Symbol

Ogg1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

31806

PubChem

31806

Alliance of Genome Resources

FB:FBgn0027864

Annotation

Keyword

Cytoplasm
DNA repair
Glycosidase
Lyase
Multifunctional enzyme
Nuclease
Nucleus
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9V3I8	dOgg1
C4IXZ6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
base-excision repair	IDA IEA IMP	24516391 26119662
cellular response to oxidative stress	IMP	26119662
base-excision repair, AP site formation	IBA
nucleotide-excision repair	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	ISS	24516391
nucleus	IBA
cytoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA
nuclease activity
DNA N-glycosylase activity	IDA	24516391
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	11095666
damaged DNA binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glycosylase

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA repair
base-excision repair, AP site formation
base-excision repair
catalytic activity
damaged DNA binding

Displaying **all 4** entries
InterPro
8-oxoguanine DNA glycosylase, N-terminal
DNA glycosylase
Helix-hairpin-helix, base-excision DNA repair, C-terminal
HhH-GPD domain

Disease

Disease Ontology

Displaying entries **21 - 26** of 26 in total

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DO ID	Disease Name	Source
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources
DOID:5520	head and neck squamous cell carcinoma	Alliance of Genome Resources
DOID:678	progressive supranuclear palsy	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9669	senile cataract	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 35 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Drosophila virilis	6634766	7244_1:0005b1
Drosophila willistoni	6638020	7260_0:000161
Drosophila simulans	6725473	7240_1:003042
Xenopus tropicalis	100380072		Xenbase:XB-GENE-995809
Drosophila suzukii	108015043	28584_0:001e79
Drosophila biarmipes	108023176	125945_0:00274c
Drosophila rhopaloa	108048488	1041015_1:003418
Drosophila takahashii	108054399	29030_0:0002ed
Drosophila kikkawai	108079165	30033_1:0011d0
Drosophila ficusphila	108088678	30025_1:000c21