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Niemann-Pick type C-1b

Summary

Gene Symbol

Npc1b

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

33072

PubChem

33072

Alliance of Genome Resources

FB:FBgn0261675

Annotation

Keyword

Cell membrane
Cholesterol metabolism
Disulfide bond
Glycoprotein
Lipid transport
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VRC9	Niemann-Pick type protein homolog 1b

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process
intestinal cholesterol absorption	IBA IMP	17339027
cholesterol transport	ISS NAS	29649482
dorsal closure	IMP	2499511
peripheral nervous system development	IMP	2499511

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium [inference]

dorsal closure

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

dorsal closure

anatomical structure development [inference]

system development [inference]

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

sterol transport

cholesterol transport

intestinal cholesterol absorption

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport

intestinal cholesterol absorption

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IEA ISM	29649482
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lipid transporter activity	NAS	29649482
cholesterol binding	IBA

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

patched

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Protein patched/dispatched
Sterol-sensing domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070113	Niemann-Pick disease type C1	Alliance of Genome Resources
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 47 in total

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Species	Gene ID	OrthoDB
Drosophila suzukii	108015432	28584_0:001dd1
Drosophila biarmipes	108027605	125945_0:0026bf
Drosophila rhopaloa	108049913	1041015_1:003469
Drosophila takahashii	108062298	29030_1:000587
Drosophila kikkawai	108080162	30033_1:0011e9
Drosophila ficusphila	108098104	30025_1:000902
Drosophila eugracilis	108109717	29029_0:00229a
Drosophila bipectinata	108133638	42026_0:00314b
Drosophila elegans	108144644	30023_0:00246f
Drosophila miranda	108165083	7229_1:0001b7

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements