GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Niemann-Pick type C-2a

Summary

Gene Symbol

Npc2a

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

33374

PubChem

33374

Alliance of Genome Resources

FB:FBgn0031381

Annotation

Keyword

Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Steroid biosynthesis

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VQ62	Niemann Pick type C2 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

« First

‹ Prev

1

2
GO Term	Evidence Code	PMID
synaptic target recognition	IMP	18817735

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

ecdysteroid biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

hormone metabolic process [inference]

hormone biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

ecdysteroid biosynthetic process

cellular process [inference]

cell recognition [inference]

neuron recognition [inference]

synaptic target recognition

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

ecdysteroid biosynthetic process

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

organic substance transport [inference]

lipid transport [inference]

sterol transport

cholesterol transport [inference]

intracellular cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport [inference]

intracellular cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of defense response to bacterium

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of defense response to bacterium

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of defense response to bacterium

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of defense response to bacterium

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

hormone biosynthetic process [inference]

ecdysteroid biosynthetic process

ecdysteroid metabolic process [inference]

ecdysteroid biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IDA	22580186

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying entries **6 - 7** of 7 in total

« First

‹ Prev

1

2
GO Term	Evidence Code	PMID
lipid antigen binding	IDA	22580186
peptidoglycan binding	IDA	22580186

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

binding [inference]

antigen binding [inference]

lipid antigen binding

lipid binding [inference]

lipopolysaccharide binding

steroid binding [inference]

cholesterol binding

lipid antigen binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

cholesterol binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

glycosaminoglycan binding [inference]

peptidoglycan binding

lipoteichoic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

NPC intracellular cholesterol transporter 2

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cholesterol binding
cholesterol efflux
intracellular cholesterol transport
sterol transport

Displaying **all 3** entries
InterPro
Immunoglobulin E-set
MD-2-related lipid-recognition domain
Sterol transport protein NPC2-like

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:22580186

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070114	Niemann-Pick disease type C2	Alliance of Genome Resources
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 49 in total

1

2

3

4

5

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10577		HGNC:14537
Mus musculus	67963		MGI:1915213
Caenorhabditis elegans	175426		WB:WBGene00006452
Danio rerio	282673		ZFIN:ZDB-GENE-021206-13
Rattus norvegicus	286898		RGD:628756
Xenopus tropicalis	493351		Xenbase:XB-GENE-6258064
Danio rerio	565099		ZFIN:ZDB-GENE-080723-11
Drosophila pseudoobscura	4817531	7237_1:002044
Drosophila ananassae	6497415	7217_1:0029e4
Drosophila yakuba	6526482	7245_1:00129c

About Release Notes Help Feedback

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.1.0

Last updated: December 9, 2024