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5-hydroxytryptamine receptor 1D

Summary

Gene Symbol

HTR1D

Organism

Homo sapiens (human)

External Links

NCBI Gene

3352

PubChem

3352

Alliance of Genome Resources

HGNC:5289

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P28221	Serotonin 1D alpha receptor Serotonin receptor 1D

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	1652050
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA	33762731
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA
chemical synaptic transmission	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

phasic smooth muscle contraction [inference]

intestine smooth muscle contraction

gastro-intestinal system smooth muscle contraction [inference]

intestine smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of locomotion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of behavior

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	1652050
plasma membrane	IBA
dendrite	IBA
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	IDA	33762731
G protein-coupled serotonin receptor activity	IMP	1652050
G protein-coupled serotonin receptor activity	IBA
neurotransmitter receptor activity	IBA
serotonin receptor activity	IDA	33762731

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **61 - 70** of 85 in total

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Species	Gene ID	Orthologous MAtrix
Cercocebus atys	105595008	CERAT06406
Aotus nancymaae	105708415	AOTNA06296
Propithecus coquereli	105815680	PROCO24038
Dipodomys ordii	105998740	DIPOR06217
Salmo salar	106562880	SALSA63282
Salmo salar	106610703	SALSA138462
Equus asinus asinus	106839990	EQUAS11048
Sinocyclocheilus grahami	107583484	SINGR11247
Sinocyclocheilus grahami	107590957	SINGR16263
Rhinopithecus bieti	108538396	RHIBE10147