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MIRAGE

5-hydroxytryptamine receptor 2C

Summary

Gene Symbol

HTR2C

Organism

Homo sapiens (human)

External Links

NCBI Gene

3358

PubChem

3358

Alliance of Genome Resources

HGNC:5295

JoGo

HTR2C

TogoVar

HTR2C

Annotation

Keyword

3D-structure
Alternative splicing
Behavior
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Proteomics identification
RNA editing
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
K9J958
P28335	5-hydroxytryptamine receptor 1C Serotonin receptor 2C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 22** of 22 in total

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GO Term	Evidence Code	PMID
positive regulation of ERK1 and ERK2 cascade	IDA	19057895
G protein-coupled serotonin receptor signaling pathway	IDA	18703043

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

serotonin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

multicellular organismal process [inference]

behavior [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

serotonin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of appetite

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
synapse	IEA
G protein-coupled serotonin receptor complex	IDA	12970106 18703043

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

G protein-coupled serotonin receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
Gq/11-coupled serotonin receptor activity	IDA	18703043 29398112
G protein-coupled serotonin receptor activity	IDA	12970106 7582481
G protein-coupled serotonin receptor activity	IBA
protein binding	IPI	14988405 25770211 28258217 28514442 30157263 32296183 33961781
neurotransmitter receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

organic cyclic compound binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gq/11-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
G protein-coupled serotonin receptor signaling pathway
chemical synaptic transmission
neurotransmitter receptor activity
phospholipase C-activating G protein-coupled receptor signaling pathway
release of sequestered calcium ion into cytosol

Displaying **all 3** entries
InterPro
5-hydroxytryptamine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:3312	bipolar disorder	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

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Last updated: April 6, 2026