iduronate 2-sulfatase

Summary
Gene Symbol
  • IDS
Aliases
  • Hunter syndrome
  • ID2S
Organism
Homo sapiens (human)
External Links
NCBI Gene
3423
HGNC
5389
KEGG Gene ID
hsa:3423
PubChem
3423
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Hydrolase
  • Lysosome
  • Metal-binding
  • Mucopolysaccharidosis
  • Reference proteome
  • Signal
  • Zymogen
Proteins
Displaying all 2 entries
UniProt Protein Name
B4DGD7
P22304
  • Alpha-L-iduronate sulfate sulfatase
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000010404

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K01136
Name
iduronate 2-sulfatase [EC:3.1.6.13]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R07821
Disease
Disease Ontology
Displaying entries 1 - 10 of 129 in total
DO ID Disease Name Source
DOID:0050451 Brugada syndrome
DOID:0050632 oculocutaneous albinism
DOID:0050635 alternating hemiplegia of childhood
DOID:0050759 myotonic dystrophy type 2
DOID:0050811 congenital adrenal hyperplasia
DOID:0050847 sleep apnea
DOID:0050848 obstructive sleep apnea
DOID:0060041 autism spectrum disorder
DOID:0060215 Balo concentric sclerosis
DOID:0060260 ptosis
The Human Phenotype Ontology
Displaying entries 1 - 10 of 109 in total
HPO ID HPO Term
HP:0000023 Inguinal hernia
HP:0000158 Macroglossia
HP:0000179 Thick lower lip vermilion
HP:0000212 Gingival overgrowth
HP:0000238 Hydrocephalus
HP:0000256 Macrocephaly
HP:0000268 Dolichocephaly
HP:0000280 Coarse facial features
HP:0000293 Full cheeks
HP:0000336 Prominent supraorbital ridges
Displaying all 3 entries
Disease ID Disease Name
ORPHA:217093
  • mucopolysaccharidosis type 2, attenuated form
ORPHA:217085
  • mucopolysaccharidosis type 2, severe form
OMIM:309900
  • mucopolysaccharidosis type 2

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024