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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Iduronate 2-sulfatase
Summary
- UniProt ID
- P22304
- Gene Symbol
-
- IDS
- SIDS
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P22304
- PubChem
- P22304
- The Human Metabolome Database
- HMDBP01594
- The O-GlcNAc Database
- P22304
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Hydrolase
- Lysosome
- Metal-binding
- Mucopolysaccharidosis
- Reference proteome
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| glycosaminoglycan catabolic process |
| heparan sulfate proteoglycan catabolic process |
| dermatan sulfate catabolic process |
| GO Term |
|---|
| cytoplasm |
| lysosome |
| lysosomal lumen |
| GO Term |
|---|
| calcium ion binding |
| iduronate-2-sulfatase activity |
Sequence
MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 87 |
|
|||
| 115 | N-linked (GlcNAc...) asparagine | |||
| 144 | N-linked (GlcNAc...) asparagine |
|
||
| 246 | N-linked (GlcNAc...) asparagine |
|
||
| 280 | N-linked (GlcNAc...) asparagine | |||
| 325 | N-linked (GlcNAc...) asparagine |
|
||
| 350 |
|
|
||
| 513 | N-linked (GlcNAc...) asparagine |
|
||
| 537 | N-linked (GlcNAc...) asparagine |
|
G49108TO
G83460ZZ
G31852PQ
G41247ZX
G02815KT
G50282JC
G84349RE
G92050GC
G28681TP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CS/DS degradation | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
| MPS II - Hunter syndrome | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:2841 | asthma | |
| DOID:0050451 | Brugada syndrome | |
| DOID:0050632 | oculocutaneous albinism | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050759 | myotonic dystrophy type 2 | |
| DOID:0050811 | congenital adrenal hyperplasia | |
| DOID:0050847 | sleep apnea | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:0060215 | Balo concentric sclerosis |
